Univ.-Prof. Dr. med. Christoph Huber
FB 04 - Universitätsmedizin, Johannes Gutenberg-Universität Mainz
- 06131/17-72 81
- 06131/17-66 78
Bobek, N.; Kuball, J.; Thaler, S. et al.
Inhibitors of apoptosis confer resistance to tumour suppression by adoptively transplanted cytotoxic T-lymphocytes in vitro and in vivoCell death and differentiation. D & D ; cdd. Bd. 12. H. 4. London: Arnold 2005 S. 317 - 325
Kindler, T.; Breitenbuecher, F.; Kasper, S. et al.
NEOPLASIA - Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML)Washington, DC: American Society of Hematology 2005 S. 335 - 340
Schuler, Martin; Green, Douglas R.; Huber, Christoph
Transcription, apoptosis and p53: catch-22Amsterdam: Elsevier 2005 S. 182 - 187
Kindler, T.; Breitenbuecher, F.; Marx, A. et al.
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS - Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemiaWashington, DC: American Society of Hematology 2004 S. 3644 - 3654
Chipuk, J.E.; Kuwana, T.; Bouchier-Hayes, L. et al.
REPORTS - CELL BIOLOGY: Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis - In addition to its well-known role as a transcription factor, the p53 tumor suppressor promotes cell death by activating a cytoplasmicWashington, DC: American Assoc. for the Advancement of Science 2004 S. 1010 - 1013
Scott, C.L.; Schuler, M.; Marsden, V.S. et al.
Research Articles - Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformationNew York, NY: Rockefeller Univ. Press 2004 S. 89 - 96
Schinzel, A.; Kaufmann, T.; Schuler, M. et al.
Research Articles - Conformational control of Bax localization and apoptotic activity by Pro 168New York, NY: Rockefeller Univ. Press 2004 S. 1021 - 1032
Hasenjäger, Anne; Gillissen, Bernhard; Müller, Antje et al.
Smac induces cytochrome c release and apoptosis independently from Bax-Bcl-xL in a strictly caspase-3-dependent manner in human carcinoma cellsBasingstoke: Nature Publ. Group 2004 S. 4523 - 4535
Dörrschuck, A.; Schmidt, A.; Schnürer, E. et al.
TRANSPLANTATION - CD8+ cytotoxic T lymphocytes isolated from allogeneic healthy donors recognize HLA class Ia-Ib-associated renal carcinoma antigens with ubiquitous or restricted tissue expressionWashington, DC: American Society of Hematology 2004 S. 2591 - 2599
Kindler, T.; Breitenbuecher, F.; Marx, A. et al.
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS - Brief report Sustained complete hematologic remission after administration of the tyrosine kinase inhibitor imatinib mesylate in a patient with refractory, secondary AMLBlood. the journal of hematology. Bd. 101. H. 8. Washington, DC: American Society of Hematology 2003 S. 2960 - 2962
Kindler, T.; Breitenbuecher, F.; Kasper, S. et al.
In BCR-ABL-positive cells, STAT-5 tyrosine-phosphorylation integrates signals induced by imatinib mesylate and Ara-CLeukemia. the journal of normal and malignant hemopoiese ; official journal of the Leukemia Research Fund U.K. Bd. 17. H. 6. Basingstoke: Nature Publ. Group 2003 S. 999 - 1009
Schuler, M.; Maurer, U.; Goldstein, J.C. et al.
p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocationLondon: Arnold 2003 S. 451 - 460
Huber, Christoph; Chipuk, J. E.; Maurer, U. et al.
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcriptionCancer Cell. Bd. Cancer Cell. 2003 S. 371-381
Milosevic, Javorina; Hoffarth, Sandra; Huber, Claudia et al.
The DNA damage-induced decrease of Bcl-2 is secondary to the activation of apoptotic effector caspasesOncogene. an international journal. Bd. 22. H. 44. Basingstoke: Nature Publ. Group 2003 S. 6852 - 6856
Huber, Christoph; Guilhot, F.; Larson, R. et al.
The IRIS Study: International Randomized study of Interferon and low-dose Ara-C versus STI571 (imatinib) in patients with newly-diagnosed chronic phase chronic myeloid leukemiaNew England Journal of Medicine. Bd. New England Journal of Medicine. 2003 S. 994-1004
Huber, Christoph; Kantarjian, C. L.; Sawyers, A. et al.
Hematologic and Cytogenetic Responses to Imatinib Mesylate in Chronic Myelogenous LeukemiaNew England Journal of Medicine. Bd. New England Journal of Medicine. 2002 S. 645-652
Hartwig, U.F.; Robbers, M.; Wickenhauser, C. et al.
TRANSPLANTATION - Murine acute graft-versus-host disease can be prevented by depletion of alloreactive T lymphocytes using activation-induced cell deathBlood. the journal of hematology. Bd. 99. H. 8. Washington, DC: American Society of Hematology 2002 S. 3041 - 3049
Britten, Cedrik M.; Meyer, Ralf G.; Kreer, Tanja et al.
The use of HLA-A*0201-transfected K562 as standard antigen-presenting cells for CD8+ T lymphocytes in IFN-g ELISPOT assaysAmsterdam [u.a.]: Elsevier 2001 S. 95 - 110
Seliger, Barbara; Hohne, Alexandra; Knuth, Alexander et al.
Analysis of the Major Histocompatibility Complex Class I Antigen Presentation Machinery in Normal and Malignant Renal Cells: Evidence for Deficiencies Associated with Transformation and ProgressionCancer research. an official organ of the American Association for Cancer Research. Bd. 56. H. 8. Birmingham, Ala. [u.a.]: AACR 1996 S. 1756 - 1760
Albrecht, T.; Schwab, R.; Peschel, C. et al.
Cationic lipide mediated transfer of c-abl and bcr antisense oligonucleotides to immature normal myeloid cells: Uptake, biological effects and modulation of gene expressionAnnals of hematology. organ of Deutsche Gesellschaft für Hämatologie und Onkologie, Gesellschaft für Thrombose- und Hämostaseforschung, Österreichische Gesellschaft für Hämatologie und Onkologie. Bd. 72. H. 2. Berlin: Springer 1996 S. 73 - 80
Nachbaur, D.; Niederwieser, D.; Aichinger, G. et al.
CD4 monoclonal antibody VIT4 in human alloimune response in vitro and in vivoImmunobiol. Bd. Immunobiol. 1996 S. 33-46
Thews, Oliver; Thews, Anne; Huber, Christoph et al.
Computer-Assisted Interpretation of Flow Cytometry Data in HematologyCytometry. the journal of the International Society for Analytical Cytology. Bd. 23. H. 2. New York, NY [u.a.]: Wiley-Liss 1996 S. 140 - 149
Decker, H.-J.H.; Neuhaus, C.; Jauch, A. et al.
Detection of a germline mutation and somatic homozygous loss of the von Hippel-Lindau tumor-suppressor gene in a family with a de novo mutation. A combined genetic study, including cytogenetics, PCR-SSCP, FISH, and CGHHuman genetics <Berlin>. Bd. 97. H. 6. Berlin: Springer 1996 S. 770 - 776
Fischer, Thomas; Aman, Javad; Kuip, Heiko van der et al.
Induction of interferon regulatory factors, 2'-5' oligoadenylate synthetase, P69 kinase and RNase L in chronic myelogenous leukaemia cells and its relationship to clinical responsivenessBritish journal of haematology. BJH ; the official journal of the British Society of Haematology. Bd. 92. H. 3. Oxford [u.a.]: Blackwell 1996 S. 595 - 603
Thaler, J.; Gastl, G.; Fluckinger, T. et al.
Interferon alpha-2c therapy of patients with chronic myelogenous leukemia: Long-term results of a multi-center phase-II studyAnnals of hematology. organ of Deutsche Gesellschaft für Hämatologie und Onkologie, Gesellschaft für Thrombose- und Hämostaseforschung, Österreichische Gesellschaft für Hämatologie und Onkologie. Bd. 72. H. 6. Berlin: Springer 1996 S. 349 - 356