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Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expressionCELL DEATH & DISEASE. Bd. 13. H. 4. 2022
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The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracilCELL BIOLOGY AND TOXICOLOGY. 2022
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Accumulation of Temozolomide-Induced Apoptosis, Senescence and DNA Damage by Metronomic Dose Schedule: A Proof-of-Principle Study with Glioblastoma CellsCANCERS. Bd. 13. H. 24. 2021
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Chronic intestinal inflammation drives colorectal tumor formation triggered by dietary heme iron in vivoARCHIVES OF TOXICOLOGY. Bd. 95. H. 7. 2021 S. 2507-2522
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Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP DepletionCELLS. Bd. 10. H. 10. 2021
Heylmann, Daniel; Ponath, Viviane; Kindler, Thomas et al.
Comparison of DNA repair and radiosensitivity of different blood cell populationsSCIENTIFIC REPORTS. Bd. 11. H. 1. 2021
Seiwert, Nina; Fahrer, Joerg; Nagel, Georg et al.
Curcumin Administered as Micellar Solution Suppresses Intestinal Inflammation and Colorectal CarcinogenesisNUTRITION AND CANCER-AN INTERNATIONAL JOURNAL. Bd. 73. H. 4. 2021 S. 686-693
Beltzig, Lea; Frumkina, Anna; Schwarzenbach, Christian et al.
Cytotoxic, Genotoxic and Senolytic Potential of Native and Micellar CurcuminNUTRIENTS. Bd. 13. H. 7. 2021
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DAZAP2 acts as specifier of the p53 response to DNA damageNUCLEIC ACIDS RESEARCH. Bd. 49. H. 5. 2021 S. 2759-2776
Toutah, Krimo; Nawar, Nabanita; Timonen, Sanna et al.
Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic LeukemiaJOURNAL OF MEDICINAL CHEMISTRY. Bd. 64. H. 12. 2021 S. 8486-8509
Mueller, Nadine; Ponkkonen, Eveliina; Carell, Thomas et al.
Direct and Base Excision Repair-Mediated Regulation of a GC-Rich cis-Element in Response to 5-Formylcytosine and 5-CarboxycytosineINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Bd. 22. H. 20. 2021
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Epigenetic Alterations Upstream and Downstream of p53 Signaling in Colorectal CarcinomaCANCERS. Bd. 13. H. 16. 2021
Dietrich, Cornelia; Hofmann, Thomas G.
Ferroptosis Meets Cell-Cell ContactsCELLS. Bd. 10. H. 9. 2021
Kadioglu, Onat; Saeed, Mohamed E. M.; Greten, Henry J. et al.
Identification of potential inhibitors targeting BRAF-V600E mutant melanoma cellsJOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. Bd. 84. H. 4. 2021 S. 1086-1089
Beltzig, L.; Stratenwerth, B.; Christmann, M. et al.
Identification of senolytic agents for sequential treatment of glioblastoma with temozolomideNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. Bd. 394. H. SUPPL 1. 2021 S. S30-S30
Berte, Nancy; Eich, Marcus; Heylmann, Daniel et al.
Impaired DNA repair in mouse monocytes compared to macrophages and precursorsDNA REPAIR. Bd. 98. 2021
Hassan, Zonera; Schneeweis, Christian; Wirth, Matthias et al.
Important role of Nfkb2 in the Kras(G12D)-driven carcinogenesis in the pancreasPANCREATOLOGY. Bd. 21. H. 5. 2021 S. 912-919
Wachholz, Vanessa; Mustafa, Al-Hassan M.; Zeyn, Yanira et al.
Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3ARCHIVES OF TOXICOLOGY. Bd. 96. H. 1. 2021 S. 177-193
Reich, Thomas R.; Schwarzenbach, Christian; Vilar, Juliana Brandstetter et al.
Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombinationCELLULAR AND MOLECULAR LIFE SCIENCES. Bd. 78. H. 14. 2021 S. 5587-5604
Marx, Christian; Sonnemann, Juergen; Beyer, Mandy et al.
Mechanistic insights into p53-regulated cytotoxicity of combined entinostat and irinotecan against colorectal cancer cellsMOLECULAR ONCOLOGY. Bd. 15. H. 12. 2021 S. 3404-3429
Haas, Bodo; Ciftcioglu, Janine; Jermar, Sanja et al.
Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependentJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. Bd. 147. H. 3. 2021 S. 779-792
Stratenwerth, Bjoern; Geisen, Susanne M.; He, Yang et al.
Molecular Dosimetry of Temozolomide: Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold DosesMOLECULAR CANCER THERAPEUTICS. Bd. 20. H. 10. 2021 S. 1789-1799
Jiso, Apisada; Demuth, Philipp; Bachowsky, Madeleine et al.
Natural Merosesquiterpenes Activate the DNA Damage Response via DNA Strand Break Formation and Trigger Apoptotic Cell Death in p53-Wild-Type and Mutant Colorectal CancerCANCERS. Bd. 13. H. 13. 2021
Mustafa, Al-Hassan M.; Kraemer, Oliver H.
Novel insight into mechanisms for ATR activation by chromatin structuresARCHIVES OF TOXICOLOGY. Bd. 95. H. 10. 2021 S. 3433-3434
Kaina, Bernd
On the Origin of SARS-CoV-2: Did Cell Culture Experiments Lead to Increased Virulence of the Progenitor Virus for Humans?IN VIVO. Bd. 35. H. 3. 2021 S. 1313-1326
Pons, Miriam; Zeyn, Yanira; Zahn, Stella et al.
Oncogenic Kinase Cascades Induce Molecular Mechanisms That Protect Leukemic Cell Models from Lethal Effects of De Novo dNTP Synthesis InhibitionCANCERS. Bd. 13. H. 14. 2021
Tomicic, Maja T.; Kraemer, Franziska; Nguyen, Alexandra et al.
Oxaliplatin-Induced Senescence in Colorectal Cancer Cells Depends on p14(ARF)-Mediated Sustained p53 ActivationCANCERS. Bd. 13. H. 9. 2021
Mueller, Nadine; Khobta, Andriy
Regulation of GC box activity by 8-oxoguanineREDOX BIOLOGY. Bd. 43. 2021
Seiwert, N.; Kostka, T.; Empl, M. et al.
Repair of O-6-carboxymethylguanine adducts by MGMT in human colonic epithelial cellsNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. Bd. 394. H. SUPPL 1. 2021 S. S12-S12
Kostka, Tina; Empl, Michael T.; Seiwert, Nina et al.
Repair of O-6-carboxymethylguanine adducts by O-6-methylguanine-DNA methyltransferase in human colon epithelial cellsCARCINOGENESIS. Bd. 42. H. 8. 2021 S. 1110-1118
Arnold, Frank; Gout, Johann; Wiese, Heike et al.
RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic CancerCANCER RESEARCH. Bd. 81. H. 7. 2021 S. 1758-1774
Goeder, Anja; Ginter, Torsten; Heinzel, Thorsten et al.
STAT1 N-terminal domain discriminatively controls type I and type II IFN signalingCYTOKINE. Bd. 144. 2021
Schmalohr, Benjamin Franz; Mustafa, Al-Hassan M.; Kraemer, Oliver H. et al.
Structural Insights into the Interaction of Heme with Protein Tyrosine Kinase JAK2**CHEMBIOCHEM. Bd. 22. H. 5. 2021 S. 861-864
Neitzel, C.; Demuth, P.; Seiwert, N. et al.
Synergism of the metabolic inhibitor CPI-613 and genotoxic chemotherapeutics in colorectal cancer therapy through a p53-independent mitochondrial apoptosis pathwayNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. Bd. 394. H. SUPPL 1. 2021 S. S7-S8
Gout, Johann; Perkhofer, Lukas; Morawe, Mareen et al.
Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancerGUT. Bd. 70. H. 4. 2021 S. 743-760
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Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide TreatmentCANCERS. Bd. 13. H. 14. 2021
Schwarzenbach, C.; Tatsch, L.; Kaina, B. et al.
Targeting the SCAP factors c-IAP1, c-IAP2 and Bcl-2 eliminates senescent cells and enhances TMZ-induced cell killing of glioblastoma cellsNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. Bd. 394. H. SUPPL 1. 2021 S. S30-S30
Walter, Karolin; Rodriguez-Aznar, Eva; Ferreira, Monica S. Ventura et al.
Telomerase and Pluripotency Factors Jointly Regulate Stemness in Pancreatic Cancer Stem CellsCANCERS. Bd. 13. H. 13. 2021
Formes, Henning; Bernardes, Joana P.; Mann, Amrit et al.
The gut microbiota instructs the hepatic endothelial cell transcriptomeISCIENCE. Bd. 24. H. 10. 2021
Liebl, Magdalena C.; Hofmann, Thomas G.
The Role of p53 Signaling in Colorectal CancerCANCERS. Bd. 13. H. 9. 2021
Kaina, Bernd
A genome-wide screening for DNA repair genes: much more players than hitherto knownSIGNAL TRANSDUCTION AND TARGETED THERAPY. Bd. 5. H. 1. 2020
Sellmer, Andreas; Pilsl, Bernadette; Beyer, Mandy et al.
A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemiaEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. Bd. 193. 2020
Ziegler, Verena; Deussen, Marco; Schumacher, Lena et al.
Anticancer drug and ionizing radiation-induced DNA damage differently influences transcription activity and DDR-related stress responses of an endothelial monolayerBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. Bd. 1867. H. 6. 2020
Matos-Rodrigues, Gabriel E.; Grigaravicius, Paulius; Lopez, Bernard S. et al.
ATRIP protects progenitor cells against DNA damage in vivoCELL DEATH & DISEASE. Bd. 11. H. 10. 2020
Matos-Rodrigues, Gabriel E.; Grigaravicius, Paulius; Lopez, Bernard S. et al.
ATRIP protects progenitor cells against DNA damage in vivo (vol 11, 923, 2020)CELL DEATH & DISEASE. Bd. 11. H. 12. 2020
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Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescenceNUCLEIC ACIDS RESEARCH. Bd. 48. H. 21. 2020 S. 12085-12101
Kaina, Bernd; Beltzig, Lea; Piee-Staffa, Andrea et al.
Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma CellsINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Bd. 21. H. 19. 2020
Rodriguez-Alvarez, M.; Sarmini, L.; Kim, D. et al.
Direct detection f mutatins arising at a damage sith in DNANAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. Bd. 393. H. SUPPL 1. 2020 S. 4-4