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Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 InhibitorsJOURNAL OF MEDICINAL CHEMISTRY. Bd. 61. H. 8. 2018 S. 3454-3477
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Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cellsCANCER LETTERS. Bd. 430. 2018 S. 34-46
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PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progressionPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Bd. 115. H. 17. 2018 S. E4061-E4070
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PNUTS at the crossroads of tumorigenesis and metastasis formationJOURNAL OF THORACIC DISEASE. Bd. 10. H. 2. 2018 S. 560-563
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Repair gene O-6-methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiationJOURNAL OF NEUROCHEMISTRY. Bd. 144. H. 2. 2018 S. 139-151
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Replica to the Opinion Letter regarding the article "Sensitization of colorectal cancer cells to irinotecan by the Survivin inhibitor LLP3 depends on XAF1 proficiency in the context of mutated p53" (Arch Toxicol https://doi.org/10.1007/s00204-018-240-x)ARCHIVES OF TOXICOLOGY. Bd. 92. H. 10. 2018 S. 3243-3244
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Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation responseCELL DEATH & DISEASE. Bd. 9. 2018
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Sensitization of colorectal cancer cells to topoisomerase I Inhibitors via pharmacological inhibition of IAPsNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. Bd. 391. 2018 S. S58-S58
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t-BuOOH induces ferroptosis in human and murine cell linesARCHIVES OF TOXICOLOGY. Bd. 92. H. 2. 2018 S. 759-775
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Targeting anticancer drug-induced senescence in glioblastoma therapyOncotarget. Bd. 9. H. 101. 2018 S. 37466 - 37467
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The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cellsARCHIVES OF TOXICOLOGY. Bd. 92. H. 7. 2018 S. 2227-2243
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XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repairCANCER LETTERS. Bd. 424. 2018 S. 119-126
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AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cellsCELL DEATH & DISEASE. Bd. 8. 2017
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Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cellsARCHIVES OF TOXICOLOGY. Bd. 91. H. 5. 2017 S. 2191-2208
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Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signalingBIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. Bd. 1868. H. 1. 2017 S. 29-39
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Class I histone deacetylases regulate p53/NF-kappa B crosstalk in cancer cellsCELLULAR SIGNALLING. Bd. 29. 2017 S. 218-225
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Cytotoxicity through BRaf inhibition by vemurafenib in combination with temozolomide or fotemustine in melanoma cellsJOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT. Bd. 15. 2017 S. 53-53
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Death of Monocytes through Oxidative Burst of Macrophages and Neutrophils: Killing in TransPLOS ONE. Bd. 12. H. 1. 2017
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DNA damage in lymphocytes of patients suffering from complex traumatizationDNA REPAIR. Bd. 52. 2017 S. 103-109
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DNA Fiber Spreading Assay to Test HDACi Effects on DNA and its ReplicationOliver H. Krämer (Hrsg). HDAC/HAT Function Assessment and Inhibitor Development: methods and Protocols, Methods in Molecular Biology. Springer Science + Business Media New York 2017
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Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcomeONCOTARGET. Bd. 8. H. 9. 2017 S. 15071-15084
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Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoterNUCLEIC ACIDS RESEARCH. Bd. 45. H. 19. 2017 S. 11033-11042
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Genotoxicity testing: Comparison of the gamma H2AX focus assay with the alkaline and neutral comet assaysMUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS. Bd. 822. 2017 S. 10-18
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HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancerONCOGENE. Bd. 36. H. 13. 2017 S. 1804-1815
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HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3CELLULAR SIGNALLING. Bd. 39. 2017 S. 9-17
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Impact of DNA repair on the dose-response of colorectal cancer formation induced by dietary carcinogensFOOD AND CHEMICAL TOXICOLOGY. Bd. 106. 2017 S. 583-594
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Increased EGFR expression induced by a novel oncogene, CUG2, confers resistance to doxorubicin through Stat1-HDAC4 signalingCELLULAR ONCOLOGY. Bd. 40. H. 6. 2017 S. 549-561
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Integrin alpha V beta 3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repairONCOTARGET. Bd. 8. H. 17. 2017 S. 27754-27771
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Interstrand Crosslink Repair as a Target for HDAC InhibitionTRENDS IN PHARMACOLOGICAL SCIENCES. Bd. 38. H. 9. 2017 S. 822-836
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Is there a Genotoxic Potential of Endodontic Root Materials?CLINICAL LABORATORY. Bd. 63. H. 4. 2017 S. 689-697
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O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignanciesLEUKEMIA. Bd. 31. H. 10. 2017 S. 2132-2142
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SUMOylation regulates the intracellular fate of ZO-2CELLULAR AND MOLECULAR LIFE SCIENCES. Bd. 74. H. 2. 2017 S. 373-392
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The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activationARCHIVES OF TOXICOLOGY. Bd. 91. H. 2. 2017 S. 967-982
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The interplay between histone deacetylases and rho kinases is important for cancer and neurodegenerationCYTOKINE & GROWTH FACTOR REVIEWS. Bd. 37. 2017 S. 29-45
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Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPasesSCIENTIFIC REPORTS. Bd. 7. 2017
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Abnormal hypermethylation at imprinting control regions in patients with S-Adenosylhomocysteine hydrolase (AHCY) deficiencyPlos One. 2016 S. 1-15
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Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) DeficiencyPLOS ONE. Bd. 11. H. 3. 2016
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Antioxidant Functions of the Aryl Hydrocarbon ReceptorSTEM CELLS INTERNATIONAL. 2016
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Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescenceONCOTARGET. Bd. 7. H. 41. 2016 S. 67235-67250
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DNA damage and the balance between survival and death in cancer biologyNATURE REVIEWS CANCER. Bd. 16. H. 1. 2016 S. 20-33
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DNA Damage Signaling Instructs Polyploid Macrophage Fate in GranulomasCELL. Bd. 167. H. 5. 2016 S. 1264-+
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Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug ResistanceCANCER RESEARCH. Bd. 76. H. 10. 2016 S. 3067-3077
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Evaluating long-term cellular effects of the arsenic species thio-DMA(V): qPCR-based gene expression as screening toolJOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. Bd. 37. 2016 S. 78-84
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Evaluating long-term cellular effects of the arsenic species thio-DMAV: qPCR-based gene expression as screening toolJournal of Trace Elements in Medicine and Biology. Bd. 37. 2016 S. 78-84
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HDAC1/HDAC2/HDAC3 mediated RAD51 and FANCD2 expression contribute to the resistance of melanoma cells to alkylating chemotherapeuticsONCOLOGY RESEARCH AND TREATMENT. Bd. 39. 2016 S. 150-150
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MGMT - A critical DNA repair gene target for chemotherapy resistanceKelley M.R., Fishel M.L. (Hrsg). DNA Repair in Cancer Therapy; Molekular Targets and Clinical Applications. Academic Press Elsevier Inc. 2016
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MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma responseCLINICAL EPIGENETICS. Bd. 8. 2016
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Nitroglycerin induces DNA damage and vascular cell death in the setting of nitrate toleranceBASIC RESEARCH IN CARDIOLOGY. Bd. 111. H. 4. 2016
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Past, present and future of immunology in MainzCELLULAR IMMUNOLOGY. Bd. 308. 2016 S. 1-6
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Quantification of Radiation Biomarkers in Leukocytes of Breast Cancer Patients Treated with Different Modalities of 3D-CRT or IMRTRADIATION RESEARCH. Bd. 186. H. 5. 2016 S. 508-519
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Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activityJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. Bd. 142. H. 1. 2016 S. 17-26
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Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating DrugsMOLECULAR CANCER THERAPEUTICS. Bd. 15. H. 11. 2016 S. 2665-2678
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The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation.Archives of Toxicology. Bd. 00. H. 00. 2016 S. 1-16
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The disulfide compound alpha-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondriaCANCER LETTERS. Bd. 371. H. 1. 2016 S. 12-19
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The disulfide compound α-lipoic acid and its derivatives: a novel class of anticancer agents targeting mitochondriaCancer Letters. Bd. 371. H. 1. 2016 S. 12-19
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The gamma H2AX DNA damage assay from a drop of bloodSCIENTIFIC REPORTS. Bd. 6. 2016
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The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repairNUCLEIC ACIDS RESEARCH. Bd. 44. H. 21. 2016 S. 10017-10030
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Widespread transcriptional gene activation initiated by a repair intermediate of 8-oxoguanineNucleic Acids Research. 2016 S. 1-14
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Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cellsBRITISH JOURNAL OF CANCER. Bd. 112. H. 2. 2015 S. 329-337
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Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testingMUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH. Bd. 763. 2015 S. 181-201
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Biodosimetry Based on gamma-H2AX Quantification and Cytogenetics after Partial- and Total-Body Irradiation during Fractionated RadiotherapyRADIATION RESEARCH. Bd. 183. H. 4. 2015 S. 432-446
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Chronic heart damage following doxorubicin treatment is alleviated by lovastatinPHARMACOLOGICAL RESEARCH. Bd. 91. 2015 S. 47-56
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DNA damage response and its impact on alkylating agent induced toxicityNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. Bd. 388. 2015 S. S73-S73
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DNA double-strand breaks induced by cytolethal distending toxin (CDT) trigger autophagy in a p53-dependent mannerNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. Bd. 388. 2015 S. S73-S74
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DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesisCARCINOGENESIS. Bd. 36. H. 10. 2015 S. 1235-1244
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Inhibition of PARP selectively sensitizes KRAS-mutant cancer cells to chemotherapy in vivo - an updateOncology Research and Treatment. Bd. 38. 2015 S. 98-99
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JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoterBIOCHEMICAL PHARMACOLOGY. Bd. 96. H. 1. 2015 S. 52-64
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Lipoic acid induces p53-independent cell death in colorectal cancer cells and enhances the cytotoxicity of 5-fluorouracilNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. Bd. 388. 2015 S. S68-S68
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Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracilARCHIVES OF TOXICOLOGY. Bd. 89. H. 10. 2015 S. 1829-1846
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Lipoic acid inhibits the DNA repair protein O-6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy inductionCARCINOGENESIS. Bd. 36. H. 8. 2015 S. 817-831
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Multidrug Efflux Pumps Attenuate the Effect of MGMT InhibitorsMOLECULAR PHARMACEUTICS. Bd. 12. H. 11. 2015 S. 3924-3934
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PARP-1 deficiency protects against colitis-associated colorectal cancerNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. Bd. 388. 2015 S. S74-S74
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Pasteurella multocida toxin-induced osteoclastogenesis requires mTOR activationCELL COMMUNICATION AND SIGNALING. Bd. 13. 2015
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Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumorsCARCINOGENESIS. Bd. 36. H. 3. 2015 S. 378-389