Kurzfassung

Oxidative stress is implicated in the pathogenesis of cardiovascular diseases. Enhanced gene expression of vascular NADPH oxidases, the major superoxide-producing enzymes in the vasculature, has been observed in patients as well as in animal models of disease. However, little is known about the mechanisms of NADPH oxidase gene expression. The present project plans to investigate the molecular control of gene transcription and mRNA stability of Nox isoforms (homologous proteins of NADPH...Oxidative stress is implicated in the pathogenesis of cardiovascular diseases. Enhanced gene expression of vascular NADPH oxidases, the major superoxide-producing enzymes in the vasculature, has been observed in patients as well as in animal models of disease. However, little is known about the mechanisms of NADPH oxidase gene expression. The present project plans to investigate the molecular control of gene transcription and mRNA stability of Nox isoforms (homologous proteins of NADPH oxidase catalytic subunit gp91phox) in response to pathological stimuli and to pharmacological compounds in vascular cells. Therapeutic potential of Nox-suppressing compounds will be studied in animal models of vascular diseases. » weiterlesen» einklappen