Kurzfassung

Intranasal delivery of antibodies to the IL-2R alpha and beta chain in a murine model of asthma:To assess the role of IL-2 signal transduction in T cells in experimental asthma, we compared the effect of intranasal administration of the antibodies to the alpha and beta chain of the IL-2 receptor (IL-2R) in vivo in a murine model of allergic asthma. In our studies, blockade of the IL-2R chain common receptor beta chain for IL-15R, but not the blockade of the alpha chain, just before allergen...Intranasal delivery of antibodies to the IL-2R alpha and beta chain in a murine model of asthma:To assess the role of IL-2 signal transduction in T cells in experimental asthma, we compared the effect of intranasal administration of the antibodies to the alpha and beta chain of the IL-2 receptor (IL-2R) in vivo in a murine model of allergic asthma. In our studies, blockade of the IL-2R chain common receptor beta chain for IL-15R, but not the blockade of the alpha chain, just before allergen challenge, led to an amelioration of airway resistance and inflammation in OVA sensitized and challenged mice.» weiterlesen» einklappen