Kurzfassung

In former studies we tested the various polysaccharide hydrogels for cytotoxicity, cytokine immobilization and release and function, cell growth, proliferation and marker gene expression after different times of culture. We demonstrated that in vitro polysaccharide especially dextran hydrogels showed a great potential for their use in biomaterial tissue engineering. Anyhow, it has to be proven, that they keep their positive characteristics in an in vivo model. Therefore, we employed an...In former studies we tested the various polysaccharide hydrogels for cytotoxicity, cytokine immobilization and release and function, cell growth, proliferation and marker gene expression after different times of culture. We demonstrated that in vitro polysaccharide especially dextran hydrogels showed a great potential for their use in biomaterial tissue engineering . Anyhow, it has to be proven, that they keep their positive characteristics in an in vivo model. Therefore, we employed an established model of critical size defects in the calvarial of mice. We analyzed hydrogels for their potential to induce bone formation and fracture healing by µCt analyses and confirmed our results with histological staining.» weiterlesen» einklappen