CRC 1066/2: Nanodimensional polymer therapeutics for tumor therapy. "Therapy of metastatic melanoma by addressing tolerance inducing M2-macrophages with therapeutic nanoparticles"
Laufzeit: 01.01.2017 - 31.12.2021
Kurzfassung
This project aims at the elimination of immune-suppression by tumor associated M2 macrophages with the help of nanoparticular carriers loaded with siRNA and low molar mass compounds to reprogram them. For this purpose R. Zentel will adjust his siRNA carrier system (cationic nanohydrogels), which have already proven its potential to deliver siRNA in vivo into macrophages in the liver. This carrier system will be optimized to the needs of this projects.
