Kurzfassung

The ability to manipulate various cell types indepently is a fundamental challenge in the analysis of complex tissues. Here we follow a strategy to translate a recently developed methodology to identify genomic fragments that can confer cell-type specific expression from cell culture to real tissues consisting of various cell types. We will use such newly identified elements to construct a library of well characterized viral vectors that allow genetic access to various cell types in the...The ability to manipulate various cell types indepently is a fundamental challenge in the analysis of complex tissues. Here we follow a strategy to translate a recently developed methodology to identify genomic fragments that can confer cell-type specific expression from cell culture to real tissues consisting of various cell types. We will use such newly identified elements to construct a library of well characterized viral vectors that allow genetic access to various cell types in the nervous tissue of mice. This project will provide a valuable toolkit for basic research, however, also serves due to its translational potential as a model for application in other tissues or pathological conditions.» weiterlesen» einklappen