Starten Sie Ihre Suche...


Durch die Nutzung unserer Webseite erklären Sie sich damit einverstanden, dass wir Cookies verwenden. Weitere Informationen

Institut für Pathobiochemie

Vorklinik / Johannes Gutenberg-Universität Mainz

Publikationen
Ergebnisse pro Seite:  100

Baeken, Marius W.; Behl, Christian

On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis

JOURNAL OF CELLULAR BIOCHEMISTRY. Bd. 123. H. 1. 2022 S. 102-114


Storck, Steffen E.; Kurtyka, Magdalena; Pietrzik, Claus U.

Brain endothelial LRP1 maintains blood-brain barrier integrity

FLUIDS AND BARRIERS OF THE CNS. Bd. 18. H. 1. 2021


Heymans, Victoria; Kunath, Sascha; Hajieva, Parvana et al.

Cell Culture Characterization of Prooxidative Chain-Transfer Agents as Novel Cytostatic Drugs

MOLECULES. Bd. 26. H. 21. 2021


Moosmann, Bernd

Flux control in the aging cascade

AGING-US. Bd. 13. H. 5. 2021 S. 6233-6235


Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara et al.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

AUTOPHAGY. Bd. 17. H. 1. 2021 S. 1-382


Behl, Christian

Integrity measures take its toll: Introducing a complete supplement issue with retractions only

JOURNAL OF CELLULAR BIOCHEMISTRY. Bd. 122. 2021 S. S7-S7


Sandin, Elvira S.; Folberth, Julica; Mueller-Fielitz, Helge et al.

Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Bd. 22. H. 9. 2021


Schepers, Jana; Behl, Christian

Lipid droplets and autophagy-links and regulations from yeast to humans

JOURNAL OF CELLULAR BIOCHEMISTRY. Bd. 122. H. 6. 2021 S. 602-611


Bres, Ewa E.; Safina, Dina; Muller, Julia et al.

Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures (vol 68, pg 2517, 2020)

GLIA. Bd. 69. H. 12. 2021 S. 2999-2999


Armbrust, Fred; Bickenbach, Kira; Koudelka, Tomas et al.

Phosphorylation of meprin beta controls its cell surface abundance and subsequently diminishes ectodomain shedding

FASEB JOURNAL. Bd. 35. H. 7. 2021


Moosmann, Bernd

Redox Biochemistry of the Genetic Code

TRENDS IN BIOCHEMICAL SCIENCES. Bd. 46. H. 2. 2021 S. 83-86


Behl, Christian

Science integrity has been never more important: It's all about trust

JOURNAL OF CELLULAR BIOCHEMISTRY. Bd. 122. H. 7. 2021 S. 694-695


Basic, Mila; Hertel, Alexandra; Bajdzienko, Justyna et al.

The deubiquitinase USP11 is a versatile and conserved regulator of autophagy

JOURNAL OF BIOLOGICAL CHEMISTRY. Bd. 297. H. 5. 2021


Colombo, Elisa; Horta, Guilherme; Roesler, Mona K. et al.

The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Bd. 118. H. 47. 2021


Behl, Christian

The search for novel targets in Alzheimer's disease-The 90s redux

Progress in Molecular Biology and Translational Science. Bd. 177. 2021 S. 123-135


Baeken, Marius W.; Schwarz, Mario; Kern, Andreas et al.

The selective degradation of sirtuins via macroautophagy in the MPP+ model of Parkinson's disease is promoted by conserved oxidation sites

CELL DEATH DISCOVERY. Bd. 7. H. 1. 2021


Pietrzik, C; Marengo, L

The Swedish dilemma - the almost exclusive use of APPswe-based mouse models impedes adequate evaluation of alternative β-secretases.

Elsevier - ScienceDirect - Biochim Biophys Acta Mol Cell Res . 2021 S. 2


Koegel, Donat; Linder, Benedikt; Brunschweiger, Andreas et al.

At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer

CELLS. Bd. 9. H. 3. 2020


Boutouja, Fahd; Platta, Harald W.

Autophagy Stimulus-Dependent Role of the Small GTPase Ras2 in Peroxisome Degradation

BIOMOLECULES. Bd. 10. H. 11. 2020


Hiebel, Christof; Sturner, Elisabeth; Hoffmeister, Meike et al.

BAG3 Proteomic Signature under Proteostasis Stress

CELLS. Bd. 9. H. 11. 2020


Moosmann, Bernd; Schindeldecker, Mario; Hajieva, Parvana

Cysteine, glutathione and a new genetic code: biochemical adaptations of the primordial cells that spread into open water and survived biospheric oxygenation

BIOLOGICAL CHEMISTRY. Bd. 401. H. 2. 2020 S. 213-231


Scharfenberg, Franka; Helbig, Andreas; Sammel, Martin et al.

Degradome of soluble ADAM10 and ADAM17 metalloproteases

CELLULAR AND MOLECULAR LIFE SCIENCES. Bd. 77. H. 2. 2020 S. 331-350



Gindorf, Markus; Storck, Steffen E.; Ohler, Anke et al.

Meprin beta: A novel regulator of blood-brain barrier integrity

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2020


Baeken, Marius W.; Weckmann, Katja; Diefenthaler, Philip et al.

Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C

CELLS. Bd. 9. H. 10. 2020


Kern, Andreas; Behl, Christian

On-demand autophagic network adaptations upon limited lipid availability

AUTOPHAGY. 2020


Kunath, Sascha; Schindeldecker, Mario; De Giacomo, Antonio et al.

Prooxidative chain transfer activity by thiol groups in biological systems

REDOX BIOLOGY. Bd. 36. 2020


Bekbulat, Fazilet; Schmitt, Daniel; Feldmann, Anne et al.

RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations

JOURNAL OF MOLECULAR BIOLOGY. Bd. 432. H. 4. 2020 S. 1216-1234


Besemer, Anna S.; Maus, Joanna; Ax, Mirjam D. A. et al.

Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis

CELLULAR AND MOLECULAR LIFE SCIENCES. 2020


Blawat, Kim; Mayr, Alexandra; Hardt, Miriam et al.

Regulation of Autophagic Signaling by Mechanical Loading and Inflammation in Human PDL Fibroblasts

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Bd. 21. H. 24. 2020


Baeken, Marius W.; Moosmann, Bernd; Hajieva, Parvana

Retrotransposon activation by distressed mitochondria in neurons

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Bd. 525. H. 3. 2020 S. 570-575


Jankauskaite, Elona; Ambroziak, Anna Maria; Hajieva, Parvana et al.

Testosterone increases apoptotic cell death and decreases mitophagy in Leber's hereditary optic neuropathy cells

JOURNAL OF APPLIED GENETICS. 2020


Christ, Maximilian G.; Clement, Albrecht M.; Behl, Christian

The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy

TRENDS IN NEUROSCIENCES. Bd. 43. H. 2. 2020 S. 79-81



van Well, Eva M.; Bader, Verian; Patra, Maria et al.

A protein quality control pathway regulated by linear ubiquitination

EMBO JOURNAL. Bd. 38. H. 9. 2019


Kodron, Agata; Hajieva, Parvana; Kulicka, Agata et al.

Analysis of BNIP3 and BNIP3L/Nix expression in cybrid cell lines harboring two LHON-associated mutations

ACTA BIOCHIMICA POLONICA. Bd. 66. H. 4. 2019 S. 427-435


Babazada, Hasan; Alekberli, Tural; Hajieva, Parvana et al.

Biosensor-based kinetic and thermodynamic characterization of opioids interaction with human mu-opioid receptor

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. Bd. 138. 2019




Van Gool, Bart; Storck, Steffen E.; Reekmans, Sara M. et al.

LRP1 Has a Predominant Role in Production over Clearance of A beta in a Mouse Model of Alzheimer's Disease

MOLECULAR NEUROBIOLOGY. Bd. 56. H. 10. 2019 S. 7234-7245


Neulen, Axel; Pantel, Tobias; Kosterhon, Michael et al.

Neutrophils mediate early cerebral cortical hypoperfusion in a murine model of subarachnoid haemorrhage

SCIENTIFIC REPORTS. Bd. 9. 2019


Neulen, Axel; Pantel, Tobias; Kosterhon, Michael et al.

Neutrophils mediate early cerebral cortical hypoperfusion in a murine model of subarachnoid haemorrhage

SCIENTIFIC REPORTS. Bd. 9. 2019


Feldmann, Lucia K.; Le Prieult, Florie; Felzen, Vanessa et al.

Proteasome and Autophagy-Mediated Impairment of Late Long-Term Potentiation (l-LTP) after Traumatic Brain Injury in the Somatosensory Cortex of Mice

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Bd. 20. H. 12. 2019



Christ, Maximilian G.; Huesmann, Heike; Nagel, Heike et al.

Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

CELLS. Bd. 8. H. 3. 2019


Kern, Andreas; Behl, Christian

Special Issue on "Proteostasis and Autophagy"

CELLS. Bd. 8. H. 7. 2019


Peters, Florian; Scharfenberg, Franka; Colmorgen, Cynthia et al.

Tethering soluble meprin alpha in an enzyme complex to the cell surface affects IBD-associated genes

FASEB JOURNAL. Bd. 33. H. 6. 2019 S. 7490-7504


Walter, Susanne; Jumpertz, Thorsten; Huettenrauch, Melanie et al.

The metalloprotease ADAMTS4 generates N-truncated A4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease

ACTA NEUROPATHOLOGICA. Bd. 137. H. 2. 2019 S. 239-257



Eggert, Simone; Gonzalez, A. C.; Thomas, C. et al.

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA

CELLULAR AND MOLECULAR LIFE SCIENCES. Bd. 75. H. 2. 2018 S. 301-322


Goel, Parul; Jumpertz, Thorsten; Ticha, Anezka et al.

Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. Bd. 28. H. 8. 2018 S. 1417-1422




Granold, Matthias; Hajieva, Parvana; Tosa, Monica Ioana et al.

Modern diversification of the amino acid repertoire driven by oxygen

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Bd. 115. H. 1. 2018 S. 41-46


Kern, Andreas; Spang, Natalie; Huesmann, Heike et al.

Novel Modulators of Proteostasis: RNAi Screen of Chromosome I in a Heat Stress Paradigm in C-elegans

CELLS. Bd. 7. H. 6. 2018


Zandl-Lang, Martina; Fanaee-Danesh, Elham; Sun, Yidan et al.

Regulatory effects of simvastatin and apoJ on APP processing and,amyloid-beta clearance in blood-brain barrier endothelial cells

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. Bd. 1863. H. 1. 2018 S. 40-60


Storck, Steffen E.; Hartz, Anika M. S.; Bernard, Jessica et al.

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

BRAIN BEHAVIOR AND IMMUNITY. Bd. 73. 2018 S. 21-33


Di Spiezio, Alessandro; Sandin, Elvira Sonia; Dore, Riccardo et al.

The LepR-mediated leptin transport across brain barriers controls food reward

MOLECULAR METABOLISM. Bd. 8. 2018 S. 13-22


Hajieva, Parvana; Baeken, Marius W.; Moosmann, Bernd

The role of Plasma Membrane Calcium ATPases (PMCAs) in neurodegenerative disorders

NEUROSCIENCE LETTERS. Bd. 663. 2018 S. 29-38


Brandscheid, Carolin; Schuck, Florian; Reinhardt, Sven et al.

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model

JOURNAL OF ALZHEIMERS DISEASE. Bd. 56. H. 2. 2017 S. 775-788


Behl, Christian

Amyloid in Alzheimer's Disease: Guilty Beyond Reasonable Doubt?

TRENDS IN PHARMACOLOGICAL SCIENCES. Bd. 38. H. 10. 2017 S. 849-851


Schoenbuehler, Bianca; Schmitt, Verena; Huesmann, Heike et al.

BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Bd. 18. H. 1. 2017


Behl, Christian; Ziegler, Christine

Beyond Amyloid - Widening the View on Alzheimer's Disease

JOURNAL OF NEUROCHEMISTRY. Bd. 143. H. 4. 2017 S. 394-395


Goel, Parul; Jumpertz, Thorsten; Mikles, David C. et al.

Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases

BIOCHEMISTRY. Bd. 56. H. 51. 2017 S. 6713-6725


Bedau, Tillmann; Peters, Florian; Prox, Johannes et al.

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin beta and promotes transendothelial cell migration

FASEB JOURNAL. Bd. 31. H. 3. 2017 S. 1226-+


Storck, Steffen E.; Pietrzik, Claus U.

Endothelial LRP1-A Potential Target for the Treatment of Alzheimer's Disease

PHARMACEUTICAL RESEARCH. Bd. 34. H. 12. 2017 S. 2637-2651


Steffen, Johannes; Krohn, Markus; Schwitlick, Christina et al.

Expression of endogenous mouse APP modulates beta-amyloid deposition in hAPP-transgenic mice

ACTA NEUROPATHOLOGICA COMMUNICATIONS. Bd. 5. 2017


Zandl, Martina; Fanaee-Danesh, Elham; Gali, Chaitanya C. et al.

INTERACTIONS OF SIMVASTATIN AND APOJ WITH AMYLOID PROCESSING IN CEREBROVASCULAR ENDOTHELIAL CELLS

ATHEROSCLEROSIS. Bd. 263. 2017 S. E85-E86


Herr, Uta-Mareike; Strecker, Paul; Storck, Steffen E. et al.

LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State

FRONTIERS IN MOLECULAR NEUROSCIENCE. Bd. 10. 2017


Sebastiani, Anne; Goelz, Christina; Sebastiani, Philipp G. et al.

Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice

FRONTIERS IN NEUROSCIENCE. Bd. 11. 2017


Wild, Klemens; August, Alexander; Pietrzik, Claus U. et al.

Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments

Frontiers in Molecular Neuroscience. Bd. 10. 2017


Reilly, R.; Mroz, M. S.; Dempsey, E. et al.

Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis

SCIENTIFIC REPORTS. Bd. 7. 2017



Becker-Pauly, Christoph; Pietrzik, Claus U.

The Metalloprotease Meprin beta Is an Alternative beta-Secretase of APP

FRONTIERS IN MOLECULAR NEUROSCIENCE. Bd. 9. 2017


Feldmann, Anne; Bekbulat, Fazilet; Huesmann, Heike et al.

The RAB GTPase RAB18 modulates macroautophagy and proteostasis

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Bd. 486. H. 3. 2017 S. 738-743


Stuerner, Elisabeth; Behl, Christian

The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease

FRONTIERS IN MOLECULAR NEUROSCIENCE. Bd. 10. 2017



Rodriguez, Andrea E.; Lopez-Crisosto, Camila; Pena-Oyarzun, Daniel et al.

BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism

AUTOPHAGY. Bd. 12. H. 2. 2016 S. 287-296


Behl, Christian

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

TRENDS IN PHARMACOLOGICAL SCIENCES. Bd. 37. H. 8. 2016 S. 672-688


Storck, Steffen E.; Meister, Sabrina; Nahrath, Julius et al.

Endothelial LRP1 transports amyloid-beta(1-42) across the blood-brain barrier

JOURNAL OF CLINICAL INVESTIGATION. Bd. 126. H. 1. 2016 S. 123-136


Schoenherr, Caroline; Bien, Jessica; Isbert, Simone et al.

Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage site

MOLECULAR NEURODEGENERATION. Bd. 11. 2016


Rabiej, Verena K.; Pflanzner, Thorsten; Wagner, Timo et al.

Low density lipoprotein receptor-related protein 1 mediated endocytosis of beta 1-integrin influences cell adhesion and cell migration

EXPERIMENTAL CELL RESEARCH. Bd. 340. H. 1. 2016 S. 102-115


Safina, Dina; Schlitt, Frederik; Romeo, Ramona et al.

Low-Density Lipoprotein Receptor-Related Protein 1 is a Novel Modulator of Radial Glia Stem Cell Proliferation, Survival, and Differentiation

GLIA. Bd. 64. H. 8. 2016 S. 1363-1380


Becker-Pauly, Christoph; Pietrzik, Claus U.

Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models

EBIOMEDICINE. Bd. 9. 2016 S. 19-20


Kundu, Arpita; Milosch, Nelli; Antonietti, Patrick et al.

Modulation of BAG3 Expression and Proteasomal Activity by sAPP alpha Does Not Require Membrane-Tethered Holo-APP

MOLECULAR NEUROBIOLOGY. Bd. 53. H. 9. 2016 S. 5985-5994


Sebastiani, Anne; Granold, Matthias; Ditter, Anja et al.

Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro-Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice

CRITICAL CARE MEDICINE. Bd. 44. H. 2. 2016 S. E70-E82


Altmann, Christine; Hardt, Stefanie; Fischer, Caroline et al.

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

NEUROBIOLOGY OF DISEASE. Bd. 96. 2016 S. 294-311


Feldmann, L. K.; Le Prieult, F.; Felzen, V. et al.

Traumatic brain injury induces changes in synaptic long-term plasticity connected to alterations in protein degradation systems

ACTA PHYSIOLOGICA. Bd. 216. 2016


Hajieva, Parvana; Moosmann, Bernd

Brain protein oxidation: what does it reflect?

NEURAL REGENERATION RESEARCH. Bd. 10. H. 11. 2015 S. 1729-1730


Arnold, Philipp; Schmidt, Frederike; Prox, Johannes et al.

Calcium negatively regulates meprin beta activity and attenuates substrate cleavage

FASEB JOURNAL. Bd. 29. H. 8. 2015 S. 3549-3557


Afrimzon, Elena; Zurgil, Naomi; Sobolev, Maria et al.

Detection and analysis of human serum albumin nanoparticles within phagocytic cells at the resolution of individual live cell or single 3D multicellular spheroid

JOURNAL OF NANOPARTICLE RESEARCH. Bd. 17. H. 12. 2015



Meister, Sabrina; Storck, Steffen E.; Hameister, Erik et al.

Expression of the ALS-causing variant hSOD1(G93A) leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. Bd. 35. H. 7. 2015 S. 1112-1121


Granold, Matthias; Moosmann, Bernd; Staib-Lasarzik, Irina et al.

High membrane protein oxidation in the human cerebral cortex

Redox Biology. Bd. 4. Amsterdam: Elsevier 2015 S. 200 - 207


Hajieva, Parvana; Bayatti, Nadhim; Granold, Matthias et al.

Membrane protein oxidation determines neuronal degeneration

JOURNAL OF NEUROCHEMISTRY. Bd. 133. H. 3. 2015 S. 352-367


Jaeckle, Felix; Schmidt, Frederike; Wichert, Rielana et al.

Metalloprotease meprin beta is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding

BIOCHEMICAL JOURNAL. Bd. 470. 2015 S. 91-103


Schindeldecker, Mario; Moosmann, Bernd

Protein-borne methionine residues as structural antioxidants in mitochondria

AMINO ACIDS. Bd. 47. H. 7. 2015 S. 1421-1432


Pasillas, Martina P.; Shields, Sarah; Reilly, Rebecca et al.

Proteomic Analysis Reveals a Role for Bcl2-associated Athanogene 3 and Major Vault Protein in Resistance to Apoptosis in Senescent Cells by Regulating ERK1/2 Activation

MOLECULAR & CELLULAR PROTEOMICS. Bd. 14. H. 1. 2015 S. 1-14


Songarj, Phuriphong; Luh, Clara; Staib-Lasarzik, Irina et al.

The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice

NEUROSCIENCE LETTERS. Bd. 584. 2015 S. 253-258


Renziehausen, Jana; Hiebel, Christof; Nagel, Heike et al.

The Cleavage Product of Amyloid-beta Protein Precursor sA beta PP alpha Modulates BAG3-Dependent Aggresome Formation and Enhances Cellular Proteasomal Activity

JOURNAL OF ALZHEIMERS DISEASE. Bd. 44. H. 3. 2015 S. 879-896