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Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS. Bd. 28. H. 8. 2018 S. 1417-1422
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Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reductionSCIENTIFIC REPORTS. Bd. 8. 2018
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Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction (vol 8, 2337, 2018)SCIENTIFIC REPORTS. Bd. 8. 2018
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Modern diversification of the amino acid repertoire driven by oxygenPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Bd. 115. H. 1. 2018 S. 41-46
Kern, Andreas; Spang, Natalie; Huesmann, Heike et al.
Novel Modulators of Proteostasis: RNAi Screen of Chromosome I in a Heat Stress Paradigm in C-elegansCELLS. Bd. 7. H. 6. 2018
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Regulatory effects of simvastatin and apoJ on APP processing and,amyloid-beta clearance in blood-brain barrier endothelial cellsBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. Bd. 1863. H. 1. 2018 S. 40-60
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The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALMBRAIN BEHAVIOR AND IMMUNITY. Bd. 73. 2018 S. 21-33
Di Spiezio, Alessandro; Sandin, Elvira Sonia; Dore, Riccardo et al.
The LepR-mediated leptin transport across brain barriers controls food rewardMOLECULAR METABOLISM. Bd. 8. 2018 S. 13-22
Hajieva, Parvana; Baeken, Marius W.; Moosmann, Bernd
The role of Plasma Membrane Calcium ATPases (PMCAs) in neurodegenerative disordersNEUROSCIENCE LETTERS. Bd. 663. 2018 S. 29-38
Brandscheid, Carolin; Schuck, Florian; Reinhardt, Sven et al.
Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse ModelJOURNAL OF ALZHEIMERS DISEASE. Bd. 56. H. 2. 2017 S. 775-788
Behl, Christian
Amyloid in Alzheimer's Disease: Guilty Beyond Reasonable Doubt?TRENDS IN PHARMACOLOGICAL SCIENCES. Bd. 38. H. 10. 2017 S. 849-851
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BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Bd. 18. H. 1. 2017
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Beyond Amyloid - Widening the View on Alzheimer's DiseaseJOURNAL OF NEUROCHEMISTRY. Bd. 143. H. 4. 2017 S. 394-395
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Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane ProteasesBIOCHEMISTRY. Bd. 56. H. 51. 2017 S. 6713-6725
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Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin beta and promotes transendothelial cell migrationFASEB JOURNAL. Bd. 31. H. 3. 2017 S. 1226-+
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Endothelial LRP1-A Potential Target for the Treatment of Alzheimer's DiseasePHARMACEUTICAL RESEARCH. Bd. 34. H. 12. 2017 S. 2637-2651
Steffen, Johannes; Krohn, Markus; Schwitlick, Christina et al.
Expression of endogenous mouse APP modulates beta-amyloid deposition in hAPP-transgenic miceACTA NEUROPATHOLOGICA COMMUNICATIONS. Bd. 5. 2017
Zandl, Martina; Fanaee-Danesh, Elham; Gali, Chaitanya C. et al.
INTERACTIONS OF SIMVASTATIN AND APOJ WITH AMYLOID PROCESSING IN CEREBROVASCULAR ENDOTHELIAL CELLSATHEROSCLEROSIS. Bd. 263. 2017 S. E85-E86
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LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric StateFRONTIERS IN MOLECULAR NEUROSCIENCE. Bd. 10. 2017
Sebastiani, Anne; Goelz, Christina; Sebastiani, Philipp G. et al.
Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult MiceFRONTIERS IN NEUROSCIENCE. Bd. 11. 2017
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Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic FragmentsFrontiers in Molecular Neuroscience. Bd. 10. 2017
Reilly, R.; Mroz, M. S.; Dempsey, E. et al.
Targeting the PI3K/Akt/mTOR signalling pathway in Cystic FibrosisSCIENTIFIC REPORTS. Bd. 7. 2017
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The Effect of Polyphenols on Protein Degradation Pathways: Implications for NeuroprotectionMOLECULES. Bd. 22. H. 1. 2017
Becker-Pauly, Christoph; Pietrzik, Claus U.
The Metalloprotease Meprin beta Is an Alternative beta-Secretase of APPFRONTIERS IN MOLECULAR NEUROSCIENCE. Bd. 9. 2017
Feldmann, Anne; Bekbulat, Fazilet; Huesmann, Heike et al.
The RAB GTPase RAB18 modulates macroautophagy and proteostasisBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Bd. 486. H. 3. 2017 S. 738-743
Stuerner, Elisabeth; Behl, Christian
The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in DiseaseFRONTIERS IN MOLECULAR NEUROSCIENCE. Bd. 10. 2017
Ohlow, Maike J.; Sohre, Selina; Granold, Matthias et al.
Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical NeuroprotectionPHARMACEUTICAL RESEARCH. Bd. 34. H. 2. 2017 S. 378-393
Rodriguez, Andrea E.; Lopez-Crisosto, Camila; Pena-Oyarzun, Daniel et al.
BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanismAUTOPHAGY. Bd. 12. H. 2. 2016 S. 287-296
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Breaking BAG: The Co-Chaperone BAG3 in Health and DiseaseTRENDS IN PHARMACOLOGICAL SCIENCES. Bd. 37. H. 8. 2016 S. 672-688
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Endothelial LRP1 transports amyloid-beta(1-42) across the blood-brain barrierJOURNAL OF CLINICAL INVESTIGATION. Bd. 126. H. 1. 2016 S. 123-136
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Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage siteMOLECULAR NEURODEGENERATION. Bd. 11. 2016
Rabiej, Verena K.; Pflanzner, Thorsten; Wagner, Timo et al.
Low density lipoprotein receptor-related protein 1 mediated endocytosis of beta 1-integrin influences cell adhesion and cell migrationEXPERIMENTAL CELL RESEARCH. Bd. 340. H. 1. 2016 S. 102-115
Safina, Dina; Schlitt, Frederik; Romeo, Ramona et al.
Low-Density Lipoprotein Receptor-Related Protein 1 is a Novel Modulator of Radial Glia Stem Cell Proliferation, Survival, and DifferentiationGLIA. Bd. 64. H. 8. 2016 S. 1363-1380
Becker-Pauly, Christoph; Pietrzik, Claus U.
Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease ModelsEBIOMEDICINE. Bd. 9. 2016 S. 19-20
Kundu, Arpita; Milosch, Nelli; Antonietti, Patrick et al.
Modulation of BAG3 Expression and Proteasomal Activity by sAPP alpha Does Not Require Membrane-Tethered Holo-APPMOLECULAR NEUROBIOLOGY. Bd. 53. H. 9. 2016 S. 5985-5994
Sebastiani, Anne; Granold, Matthias; Ditter, Anja et al.
Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro-Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult MiceCRITICAL CARE MEDICINE. Bd. 44. H. 2. 2016 S. E70-E82
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Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagyNEUROBIOLOGY OF DISEASE. Bd. 96. 2016 S. 294-311
Feldmann, L. K.; Le Prieult, F.; Felzen, V. et al.
Traumatic brain injury induces changes in synaptic long-term plasticity connected to alterations in protein degradation systemsACTA PHYSIOLOGICA. Bd. 216. 2016
Hajieva, Parvana; Moosmann, Bernd
Brain protein oxidation: what does it reflect?NEURAL REGENERATION RESEARCH. Bd. 10. H. 11. 2015 S. 1729-1730
Arnold, Philipp; Schmidt, Frederike; Prox, Johannes et al.
Calcium negatively regulates meprin beta activity and attenuates substrate cleavageFASEB JOURNAL. Bd. 29. H. 8. 2015 S. 3549-3557
Afrimzon, Elena; Zurgil, Naomi; Sobolev, Maria et al.
Detection and analysis of human serum albumin nanoparticles within phagocytic cells at the resolution of individual live cell or single 3D multicellular spheroidJOURNAL OF NANOPARTICLE RESEARCH. Bd. 17. H. 12. 2015
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Estrogen receptor alpha regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 functionCELL DEATH & DISEASE. Bd. 6. 2015
Meister, Sabrina; Storck, Steffen E.; Hameister, Erik et al.
Expression of the ALS-causing variant hSOD1(G93A) leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier modelJOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. Bd. 35. H. 7. 2015 S. 1112-1121
Granold, Matthias; Moosmann, Bernd; Staib-Lasarzik, Irina et al.
High membrane protein oxidation in the human cerebral cortexRedox Biology. Bd. 4. Amsterdam: Elsevier 2015 S. 200 - 207
Hajieva, Parvana; Bayatti, Nadhim; Granold, Matthias et al.
Membrane protein oxidation determines neuronal degenerationJOURNAL OF NEUROCHEMISTRY. Bd. 133. H. 3. 2015 S. 352-367
Jaeckle, Felix; Schmidt, Frederike; Wichert, Rielana et al.
Metalloprotease meprin beta is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP sheddingBIOCHEMICAL JOURNAL. Bd. 470. 2015 S. 91-103
Schindeldecker, Mario; Moosmann, Bernd
Protein-borne methionine residues as structural antioxidants in mitochondriaAMINO ACIDS. Bd. 47. H. 7. 2015 S. 1421-1432
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Proteomic Analysis Reveals a Role for Bcl2-associated Athanogene 3 and Major Vault Protein in Resistance to Apoptosis in Senescent Cells by Regulating ERK1/2 ActivationMOLECULAR & CELLULAR PROTEOMICS. Bd. 14. H. 1. 2015 S. 1-14
Songarj, Phuriphong; Luh, Clara; Staib-Lasarzik, Irina et al.
The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in miceNEUROSCIENCE LETTERS. Bd. 584. 2015 S. 253-258
Renziehausen, Jana; Hiebel, Christof; Nagel, Heike et al.
The Cleavage Product of Amyloid-beta Protein Precursor sA beta PP alpha Modulates BAG3-Dependent Aggresome Formation and Enhances Cellular Proteasomal ActivityJOURNAL OF ALZHEIMERS DISEASE. Bd. 44. H. 3. 2015 S. 879-896