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Institut für Pathobiochemie

Vorklinik / Johannes Gutenberg-Universität Mainz

Publikationen
Ergebnisse pro Seite:  100

Hiebel, Christof; Behl, Christian

The complex modulation of lysosomal degradation pathways by cannabinoid receptors 1 and 2

LIFE SCIENCES. Bd. 138. 2015 S. 3-7


Kern, Andreas; Dikic, Ivan; Behl, Christian

The integration of autophagy and cellular trafficking pathways via RAB GAPs

AUTOPHAGY. Bd. 11. H. 12. 2015 S. 2393-2397


Hiebel, Christof; Kromm, Tanja; Stark, Marcel et al.

Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex

JOURNAL OF NEUROCHEMISTRY. Bd. 131. H. 4. 2014 S. 484-497


Liebl, Martina P.; Kaya, Ali M.; Tenzer, Stefan et al.

Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis

FREE RADICAL BIOLOGY AND MEDICINE. Bd. 72. 2014 S. 41-54


Brendel, Alexander; Renziehausen, Jana; Behl, Christian et al.

Downregulation of PMCA2 increases the vulnerability of midbrain neurons to mitochondrial complex I inhibition

NEUROTOXICOLOGY. Bd. 40. 2014 S. 43-51


Milosch, N.; Tanrioever, G.; Kundu, A. et al.

Holo-APP and G-protein-mediated signaling are required for sAPP alpha-induced activation of the Akt survival pathway

CELL DEATH & DISEASE. Bd. 5. 2014


Tucher, Joanna; Linke, Dennis; Koudelka, Tomas et al.

Lc-ms based cleavage site profiling of the proteases adam10 and adam17 using proteome-derived peptide libraries

Journal of proteome research. Bd. 13. H. 4. Washington: American Chemical Society 2014 S. 2205 - 2214


Liebl, Martina P.; Windschmitt, Johannes; Besemer, Anna S. et al.

Low-frequency magnetic fields do not aggravate disease in mouse models of Alzheimer's disease and amyotrophic lateral sclerosis

Scientific reports. Bd. 5. London: Nature Publishing Group 2014 Art. 8585


Liebl, M.; Windschmitt, J.; Schaefer, A-K. et al.

Potential effect of low-frequency magnetic fields (LF-MFs) on mouse models of amyotrophic lateral sclerosis and Alzheimer's disease

ACTA PHYSIOLOGICA. Bd. 210. 2014 S. 168-168


Spang, Natalie; Feldmann, Anne; Huesmann, Heike et al.

RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy

Autophagy. Bd. 10. H. 12. Austin, Tex.: Landes Bioscience 2014 S. 2297 - 2309



Stark, Marcel; Behl, Christian

The Ginkgo biloba Extract EGb 761 Modulates Proteasome Activity and Polyglutamine Protein Aggregation

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2014


Vera, Naira P. Martinez; Schmidt, Reinhold; Langer, Klaus et al.

Tracking of Magnetite Labeled Nanoparticles in the Rat Brain Using MRI

PLOS ONE. Bd. 9. H. 3. 2014


Weichert, Anna; Besemer, Anna S.; Liebl, Martina et al.

Wild-type Cu/Zn superoxide dismutase stabilizes mutant variants by heterodimerization

NEUROBIOLOGY OF DISEASE. Bd. 62. 2014 S. 479-488


Stumm, Christoph; Hiebel, Christof; Hanstein, Regina et al.

Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition

Neurobiology of aging. Bd. 34. H. 11. New York, NY: Elsevier 2013 S. 2574 - 2584


Gil, So YouN. G.; Youn, Byung-Soo; Byun, Kyunghee et al.

Clusterin and lrp2 are critical components of the hypothalamic feeding regulatory pathway

Nature communications. Bd. 4. London: Nature Publishing Group 2013 Art. 1862


Gil, So Young; Youn, Byung-Soo; Byun, Kyunghee et al.

Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway (vol 4, 1862, 2013)

NATURE COMMUNICATIONS. Bd. 4. 2013


Kohl, Tobias; Gehrke, Nadine; Schad, Arno et al.

Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells

Cell death & disease. Bd. 2013. H. 4. London: Nature Publishing Group 2013 e712


Brendel, Alexander; Felzen, Vanessa; Morawe, Tobias et al.

Differential regulation of apoptosis-associated genes by estrogen receptor alpha in human neuroblastoma cells

RESTORATIVE NEUROLOGY AND NEUROSCIENCE. Bd. 31. H. 2. 2013 S. 199-211


Maier, Wladislaw; Bednorz, Mariola; Meister, Sabrina et al.

LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype

Molecular neurodegeneration. Bd. 8. London u.a.: BioMed central 2013 Art. 25


Meister, Sabrina; Zlatev, Iavor; Stab, Julia et al.

Nanoparticulate flurbiprofen reduces amyloid-beta(42) generation in an in vitro blood-brain barrier model

ALZHEIMERS RESEARCH & THERAPY. Bd. 5. H. 6. 2013


Meister,, S.; Zlatev,, I.; Stab,, J. et al.

Nanoparticulate flurbiprofen reduces amyloid-beta42 generation in an in vitro blood-brain barrier model

Alzheimers Res Ther. Bd. 5. H. 51. 2013 S. 5, 51


De Giacomo, Antonio J.; Behl, Christian; Hajieva, Parvana

Phenothiazine-mediated lifespan extension in Caenorhabditis elegans

EXPERIMENTAL GERONTOLOGY. Bd. 48. H. 7. 2013 S. 690-690


Wagner, Timo; Dieckmann, Marco; Jaeger, Sebastian et al.

Stx5 is a novel interactor Of VLDL-R to affect its intracellular trafficking and processing

EXPERIMENTAL CELL RESEARCH. Bd. 319. H. 13. 2013 S. 1956-1972



Jefferson, Tamara; Keller, Ulrich Auf Dem; Bellac, Caroline et al.

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin beta and ADAM10

CELLULAR AND MOLECULAR LIFE SCIENCES. Bd. 70. H. 2. 2013 S. 309-333


Korac, Jelena; Schaeffer, Veronique; Kovacevic, Igor et al.

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

JOURNAL OF CELL SCIENCE. Bd. 126. H. 2. 2013 S. 580-592


Isbert, S; Wagner, K; Eggert, S et al.

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

CELLULAR AND MOLECULAR LIFE SCIENCES. Bd. 69. H. 8. 2012 S. 1353-1375


Behl, C

Brain aging and late-onset Alzheimer's disease: many open questions

INTERNATIONAL PSYCHOGERIATRICS. Bd. 24. 2012 S. S3-S9


Pflanzner, T; Petsch, B; Andre-Dohmen, B et al.

Cellular prion protein participates in amyloid-beta transcytosis across the blood-brain barrier

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. Bd. 32. H. 4. 2012 S. 628-632


Zettl, H; Ness, J; Hahnke, V et al.

Discovery of gamma-Secretase Modulators with a Novel Activity Profile by Text-Based Virtual Screening

ACS CHEMICAL BIOLOGY. Bd. 7. H. 9. 2012 S. 1488-1495


Wiens, M; Link, T; Elkhooly, TA et al.

Formation of a micropatterned titania photocatalyst by microcontact printed silicatein on gold surfaces

CHEMICAL COMMUNICATIONS. Bd. 48. H. 92. 2012 S. 11331-11333



Klionsky, DJ; Abdalla, FC; Abeliovich, H et al.

Guidelines for the use and interpretation of assays for monitoring autophagy

AUTOPHAGY. Bd. 8. H. 4. 2012 S. 445-544


Ohlow, MJ; Granold, M; Schreckenberger, M et al.

Is the chromanol head group of vitamin E nature's final truth on chain-breaking antioxidants?

FEBS LETTERS. Bd. 586. H. 6. 2012 S. 711-716


Jumpertz, Thorsten; Rennhack, Andreas; Ness, Julia et al.

Presenilin is the molecular target of acidic gamma-secretase modulators in living cells

PLoS one. Bd. 7. H. 1. Lawrence, Kan.: PLoS 2012 e30484


Fuhrmeister, Jessica; Tews, Martha; Kromer, Andrea et al.

Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells

TOXICOLOGY LETTERS. Bd. 215. H. 3. 2012 S. 219-227


Morawe, T; Hiebel, C; Kern, A et al.

Protein Homeostasis, Aging and Alzheimer's Disease

MOLECULAR NEUROBIOLOGY. Bd. 46. H. 1. 2012 S. 41-54


Kogel, D; Deller, T; Behl, C

Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging

EXPERIMENTAL BRAIN RESEARCH. Bd. 217. H. 3-4. 2012 S. 471-479


Rennhack, A; Jumpertz, T; Ness, J et al.

Synthesis of a potent photoreactive acidic gamma-secretase modulator for target identification in cells

BIOORGANIC & MEDICINAL CHEMISTRY. Bd. 20. H. 21. 2012 S. 6523-6532


Buchner, B; Gallenmuller, C; Lautenschlager, R et al.

The German Network for Mitochondrial Disorders (mitoNET)

MEDIZINISCHE GENETIK. Bd. 24. H. 3. 2012 S. 193-199


Bien, J; Jefferson, T; Causevic, M et al.

The Metalloprotease Meprin beta Generates Amino Terminal-truncated Amyloid beta Peptide Species

JOURNAL OF BIOLOGICAL CHEMISTRY. Bd. 287. H. 40. 2012 S. 33304-33313


Muller, UC; Pietrzik, CU; Deller, T

The physiological functions of the beta-amyloid precursor protein APP

EXPERIMENTAL BRAIN RESEARCH. Bd. 217. H. 3-4. 2012 S. 325-329


Wagner, T; Pietrzik, CU

The role of lipoprotein receptors on the physiological function of APP

EXPERIMENTAL BRAIN RESEARCH. Bd. 217. H. 3-4. 2012 S. 377-387



Wagner, Sylvia; Zensi, Anja; Wien, Sascha L. et al.

Uptake mechanism of apoe-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model

PLoS one. Bd. 7. H. 3. Lawrence, Kan.: PLoS 2012 e32568


Rolyan, H; Feike, A; Upadhaya, A et al.

Amyloid-beta protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease

JOURNAL OF NEURAL TRANSMISSION. Bd. 118. H. 5. 2011 S. 699-712



Gamerdinger, M; Kaya, AM; Wolfrum, U et al.

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

EMBO REPORTS. Bd. 12. H. 2. 2011 S. 149-156


Witte, I; Altenhofer, S; Wilgenbus, P et al.

Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells

CELL DEATH & DISEASE. Bd. 2. 2011 S. -


Schindeldecker, M; Stark, M; Behl, C et al.

Differential cysteine depletion in respiratory chain complexes enables the distinction of longevity from aerobicity

MECHANISMS OF AGEING AND DEVELOPMENT. Bd. 132. H. 4. 2011 S. 171-179


Gamerdinger, M; Carra, S; Behl, C

Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins

JOURNAL OF MOLECULAR MEDICINE-JMM. Bd. 89. H. 12. 2011 S. 1175-1182


Ohlow, MJ; Moosmann, B

Foundation review: Phenothiazine: the seven lives of pharmacology's first lead structure

DRUG DISCOVERY TODAY. Bd. 16. H. 3-4. 2011 S. 119-131



Pflanzner, T; Janko, MC; Andre-Dohmen, B et al.

LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier

NEUROBIOLOGY OF AGING. Bd. 32. H. 12. 2011 S. -


Jefferson, T; Causevic, M; Keller, UAD et al.

Metalloprotease Meprin beta Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo

JOURNAL OF BIOLOGICAL CHEMISTRY. Bd. 286. H. 31. 2011 S. 27741-27750


Heneka, MT; Kummer, MP; Weggen, S et al.

Molecular Mechanisms and Therapeutic Application of NSAIDs and Derived Compounds in Alzheimer's Disease

CURRENT ALZHEIMER RESEARCH. Bd. 8. H. 2. 2011 S. 115-131


Meng, FJ; Yao, DD; Shi, Y et al.

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

MOLECULAR NEURODEGENERATION. Bd. 6. 2011 S. -



Moosmann, B

Respiratory chain cysteine and methionine usage indicate a causal role for thiyl radicals in aging

EXPERIMENTAL GERONTOLOGY. Bd. 46. H. 2-3. 2011 S. 164-169


Pflanzner, T; Kuhlmann, CR; Pietrzik, CU

Blood-Brain-Barrier Models for the Investigation of Transporter- and Receptor-Mediated Amyloid-beta Clearance in Alzheimer's Disease

CURRENT ALZHEIMER RESEARCH. Bd. 7. H. 7. 2010 S. 578-590


Ohlow, MJ; Mocko, JB; Behl, C et al.

Comparative Evaluation of Biochemical Antioxidants as Neuroprotective Agents

FREE RADICAL BIOLOGY AND MEDICINE. Bd. 49. 2010 S. S192-S192


Kern, A; Ackermann, B; Clement, AM et al.

HSF1-Controlled and Age-Associated Chaperone Capacity in Neurons and Muscle Cells of C. elegans

PLOS ONE. Bd. 5. H. 1. 2010 S. -


Reekmans, Sara M.; Pflanzner, Thorsten; Gordts, Philip L. S. M. et al.

Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis

Cellular and molecular life sciences. Bd. 67. H. 1. Basel: Springer 2010 S. 135 - 145


Pflanzner, T; Reekmanns, SM; Gordts, PLSM et al.

Inactivation of the proximal NPxY motif impairs early steps in LRP1 biosynthesis

EUROPEAN JOURNAL OF CELL BIOLOGY. Bd. 89. 2010 S. 37-37


Luh, C; Kuhlmann, CR; Ackermann, B et al.

Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury

JOURNAL OF NEUROCHEMISTRY. Bd. 112. H. 4. 2010 S. 1015-1025


Granold, M; Moosmann, B; Behl, C et al.

Integral Membrane Proteins are the Predominant Site of Protein Oxidation in the Aged CNS and in Alzheimer's Disease

FREE RADICAL BIOLOGY AND MEDICINE. Bd. 49. 2010 S. S155-S155


Dieckmann, M; Dietrich, MF; Herz, J

Lipoprotein receptors - an evolutionarily ancient multifunctional receptor family

BIOLOGICAL CHEMISTRY. Bd. 391. H. 11. 2010 S. 1341-1363


Pflanzner, T; Janko, MC; Kuhlmann, CRW et al.

Low density lipoprotein receptor-related protein 1 is a receptor for bidirectional transcytosis of amyloid-beta across the blood-brain-barrier

EUROPEAN JOURNAL OF CELL BIOLOGY. Bd. 89. 2010 S. 26-26


Altenhofer, S; Witte, I; Teiber, JF et al.

One Enzyme, Two Functions PON2 PREVENTS MITOCHONDRIAL SUPEROXIDE FORMATION AND APOPTOSIS INDEPENDENT FROM ITS LACTONASE ACTIVITY

JOURNAL OF BIOLOGICAL CHEMISTRY. Bd. 285. H. 32. 2010 S. 24398-24403



Kirschbaum, KM; Uhr, M; Holthoewer, D et al.

Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice

NEUROPHARMACOLOGY. Bd. 59. H. 6. 2010 S. 474-479


Mocko, JB; Kern, A; Moosmann, B et al.

Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease

NEUROBIOLOGY OF DISEASE. Bd. 40. H. 1. 2010 S. 120-129


Haege, S; Galetzka, D; Zechner, U et al.

Spatial Learning and Expression Patterns of PP1 mRNA in Mouse Hippocampus

NEUROPSYCHOBIOLOGY. Bd. 61. H. 4. 2010 S. 188-196


Moosmann, B; Hajieva, P; Behl, C

The Advent of Molecular Oxygen in the Biosphere Triggered the Introduction of the Last Two Amino Acids into the Genetic Code

FREE RADICAL BIOLOGY AND MEDICINE. Bd. 49. 2010 S. S88-S88


Schindeldecker, M; Moosmann, B

The Differential Avoidance of Cysteine Residues in Respiratory Chain Complexes Reflects Both Longevity and Aerobicity

FREE RADICAL BIOLOGY AND MEDICINE. Bd. 49. 2010 S. S85-S85


Manthey, D; Gamerdinger, M; Behl, C

The selective beta(1)-adrenoceptor antagonist nebivolol is a potential oestrogen receptor agonist with neuroprotective abilities

BRITISH JOURNAL OF PHARMACOLOGY. Bd. 159. H. 6. 2010 S. 1264-1273