SFB 432: Mechanismen der Tumorabwehr und ihre therapeutische Beeinflussung
Forschungsverbund / Johannes Gutenberg-Universität Mainz
Erlach, KC; Bohm, V; Knabe, M et al.
Activation of hepatic natural killer cells and control of liver-adapted lymphoma in the murine model of cytomegalovirus infection.Med Microbiol Immunol. Bd. 197. H. 2. 2008 S. 167-78
Distler, E; Wolfel, C; Kohler, S et al.
Acute myeloid leukemia (AML)-reactive cytotoxic T lymphocyte clones rapidly expanded from CD8(+) CD62L((high)+) T cells of healthy donors prevent AML engraftment in NOD/SCID IL2Rgamma(null) mice.Exp Hematol. Bd. 36. H. 4. 2008 S. 451-63
Holtappels, R; Bohm, V; Podlech, J et al.
CD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model.Med Microbiol Immunol. Bd. 197. H. 2. 2008 S. 125-34
Sahin, U; Koslowski, M; Dhaene, K et al.
Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development.Clin Cancer Res. Bd. 14. H. 23. 2008 S. 7624-34
Wolfel, C; Lennerz, V; Lindemann, E et al.
Dissection and molecular analysis of alloreactive CD8+ T cell responses in allogeneic haematopoietic stem cell transplantation.Cancer Immunol Immunother. Bd. 57. H. 6. 2008 S. 849-57
Cicin-Sain, L; Ruzsics, Z; Podlech, J et al.
Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an antiapoptotic viral gene.J Virol. Bd. 82. H. 5. 2008 S. 2056-64
Bohm, V; Podlech, J; Thomas, D et al.
Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy.Med Microbiol Immunol. Bd. 197. H. 2. 2008 S. 135-44
Tschiedel, S; Gentilini, C; Lange, T et al.
Identification of NM23-H2 as a tumour-associated antigen in chronic myeloid leukaemia.Leukemia. Bd. 22. H. 8. 2008 S. 1542-50
Javorovic, M; Wilde, S; Zobywalski, A et al.
Inhibitory effect of RNA pool complexity on stimulatory capacity of RNA-pulsed dendritic cells.J Immunother. Bd. 31. H. 1. 2008 S. 52-62
Wirtz, N; Schader, SI; Holtappels, R et al.
Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues.Med Microbiol Immunol. Bd. 197. H. 2. 2008 S. 151-8
Holtappels, R; Simon, CO; Munks, MW et al.
Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination.J Virol. Bd. 82. H. 12. 2008 S. 5781-96
Hahnel, PS; Thaler, S; Antunes, E et al.
Targeting AKT signaling sensitizes cancer to cellular immunotherapy.Cancer Res. Bd. 68. H. 10. 2008 S. 3899-906
Sacher, T; Podlech, J; Mohr, CA et al.
The major virus-producing cell type during murine cytomegalovirus infection, the hepatocyte, is not the source of virus dissemination in the host.Cell Host Microbe. Bd. 3. H. 4. 2008 S. 263-72
Graf, C; Heidel, F; Tenzer, S et al.
A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cells.Blood. Bd. 109. H. 7. 2007 S. 2985-8
Koslowski, M; Sahin, U; Mitnacht-Kraus, R et al.
A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes.Cancer Res. Bd. 67. H. 19. 2007 S. 9528-34
Roos, WP; Batista, LFZ; Naumann, S et al.
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanineOncogene. Bd. 26. 2007 S. 186-197
Kuball, J; Dossett, ML; Wolfl, M et al.
Facilitating matched pairing and expression of TCR chains introduced into human T cells.Blood. Bd. 109. H. 6. 2007 S. 2331-8
Briegert, M; Kaina, B
Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agentsCancer Res. Bd. 67. 2007 S. 26-31
Tuettenberg, A; Koelsch, S; Knop, J et al.
Oxymetazoline modulates proinflammatory cytokines and the T-cell stimulatory capacity of dendritic cells.Exp Dermatol. Bd. 16. 2007 S. 171-178
Besold, K; Frankenberg, N; Pepperl-Klindworth, S et al.
Processing and MHC class I presentation of human cytomegalovirus pp65-derived peptides persist despite gpUS2-11-mediated immune evasionJ Gen Virol. Bd. 88. 2007 S. 1429-1439
Meyer, RG; Britten, CM; Wehler, D et al.
Prophylactic transfer of CD8-depleted donor lymphocytes after T-cell-depleted reduced-intensity transplantation.Blood. Bd. 109. H. 1. 2007 S. 374-82
Meyer, RG; Graf, C; Britten, CM et al.
Rapid identification of an HLA-B*1501-restricted vaccinia peptide antigen.Vaccine. Bd. 25. H. 24. 2007 S. 4715-22
Cornelissen, JJ; van Putten, WL; Verdonck, LF et al.
Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?Blood. Bd. 109. H. 9. 2007 S. 3658-66
Kreiter, S; Konrad, T; Sester, M et al.
Simultaneous ex vivo quantification of antigen-specific CD4+ and CD8+ T cell responses using in vitro transcribed RNA.Cancer Immunol Immunother. Bd. 56. H. 10. 2007 S. 1577-87
Wehler, TC; Nonn, M; Brandt, B et al.
Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines.Blood. Bd. 109. H. 1. 2007 S. 365-73
Blank, C; Kuball, J; Voelkl, S et al.
Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro.Int J Cancer. Bd. 119. H. 2. 2006 S. 317-27
Christmann, M; Tomicic, MT; Origer, D et al.
c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the resynthesis of XPFNucleic Acids Res. Bd. 34. 2006 S. 6530-6539
Simon, CO; Holtappels, R; Tervo, HM et al.
CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation.J Virol. Bd. 80. H. 21. 2006 S. 10436-56
Holtappels, R; Munks, MW; Podlech, J et al.
CD8 T-cell-based immunotherapy of cytomegalovirus disease in the mouse model of the immunocompromised bone marrow transplantation recipientM. J. Reddehase (ed.), Cytomegaloviruses: molecular biology and immunology. 1. Aufl. Wymondham, Norfolk, United Kingdom: Caister Academic Press 2006
Kiesslich, R; Hoffman, A; Neurath, MF
Colonoscopy, tumors, and inflammatory bowel disease - new diagnostic methods.Endoscopy. Bd. 38. H. 1. 2006 S. 5-10
Holtappels, R; Gillert-Marien, D; Thomas, D et al.
Cytomegalovirus encodes a positive regulator of antigen presentation.J Virol. Bd. 80. H. 15. 2006 S. 7613-24
Pepperl-Klindworth, S; Besold, K; Frankenberg, N et al.
Cytomegalovirus Interleukin-10 Expression in Infected Cells Does Not Impair MHC Class I Restricted Peptide Presentation on Bystanding Antigen-Presenting CellsViral Immunol. Bd. 19. H. 1. 2006 S. 92-101
Schadendorf, D; Ugurel, S; Schuler-Thurner, B et al.
Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG.Ann Oncol. Bd. 17. 2006 S. 563-570
Hartwig, UF; Nonn, M; Khan, S et al.
Depletion of alloreactive T cells via CD69: implications on antiviral, antileukemic and immunoregulatory T lymphocytes.Bone Marrow Transpl. Bd. 37. H. 3. 2006 S. 297-305
Roos, WP; Kaina, B
DNA damage-induced cell death by apoptosisTrends in Molecular Medicine. Bd. 12. H. 9. 2006 S. 440-450
Steitz, J; Britten, CM; Wolfel, T et al.
Effective induction of anti-melanoma immunity following genetic vaccination with synthetic mRNA coding for the fusion protein EGFP.TRP2.Cancer Immunol Immunother. Bd. 55. H. 3. 2006 S. 246-53
Steitz, J; Buchs, S; Tormo, D et al.
Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin.Int J Cancer. Bd. 118. H. 2. 2006 S. 373-80
Kuphal, S; Wallner, S; Schimanski, CC et al.
Expression of Hugl-1 is strongly reduced in malignant melanoma.Oncogene. Bd. 25. H. 1. 2006 S. 103-10
Grunwald, C; Koslowski, M; Arsiray, T et al.
Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer.Int J Cancer. Bd. 118. H. 10. 2006 S. 2522-8
Klamp, T; Sahin, U; Kyewski, B et al.
Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues.Immunol Lett. Bd. 106. H. 2. 2006 S. 172-9
Tureci, O; Mack, U; Luxemburger, U et al.
Humoral immune responses of lung cancer patients against tumor antigen NY-ESO-1.Cancer Lett. Bd. 236. H. 1. 2006 S. 64-71
Wu, J; Helftenbein, G; Koslowski, M et al.
Identification of new claudin family members by a novel PSI-BLAST based approach with enhanced specificity.Proteins. Bd. 65. H. 4. 2006 S. 808-15
Tüttenberg, A; Becker, C; Hüter, E et al.
Induction of strong and persistent MelanA/MART-1-specific immune responses by adjuvant dendritic cell-based vaccination of stage II melanoma patients.Int J Cancer. Bd. 118. 2006 S. 2617-2627
Bornhauser, M; Thiede, C; Babatz, J et al.
Infusion of bcr/abl peptide-reactive donor T cells to achieve molecular remission of chronic myeloid leukemia after CD34+ selected allogeneic hematopoietic cell transplantation.Leukemia. Bd. 20. H. 11. 2006 S. 2055-7
Erlach, KC; Böhm, V; Seckert, CK et al.
Lymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infection.J Virol. Bd. 80. H. 10. 2006 S. 4801-19
Holtkamp, S; Kreiter, S; Selmi, A et al.
Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells.Blood. Bd. 108. H. 13. 2006 S. 4009-17
Su, Z; Kuball, J; Barreiros, AP et al.
Nitric oxide promotes resistance to tumor suppression by CTLs.J Immunol. Bd. 176. H. 7. 2006 S. 3923-30
Chromik, J; Schnurer, E; Meyer, RG et al.
Proteasome-inhibited dendritic cells demonstrate improved presentation of exogenous synthetic and natural HLA-class I peptide epitopes.J Immunol Methods. Bd. 308. H. 1-2. 2006 S. 77-89
Sahin, U; Tureci, O; Graf, C et al.
Rapid molecular dissection of viral and bacterial immunomes.Eur J Immunol. Bd. 36. H. 4. 2006 S. 1049-57
Voss, RH; Kuball, J; Engel, R et al.
Redirection of T cells by delivering a transgenic mouse-derived MDM2 tumor antigen-specific TCR and its humanized derivative is governed by the CD8 coreceptor and affects natural human TCR expression.Immunol Res. Bd. 34. H. 1. 2006 S. 67-87
Wehler, T; Wolfert, F; Schimanski, CC et al.
Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease.Oncol Rep. Bd. 16. H. 6. 2006 S. 1159-64
Kausche, S; Wehler, T; Schnürer, E et al.
Superior antitumor in vitro responses of allogeneic matched sibling compared with autologous patient CD8+ T cells.Cancer Res. Bd. 66. H. 23. 2006 S. 11447-11454
Koslowski, M; Sahin, U; Huber, C et al.
The human X chromosome is enriched for germline genes expressed in premeiotic germ cells of both sexes.Hum Mol Genet. Bd. 15. H. 15. 2006 S. 2392-9
Tsaryk, R; Fabian, K; Thacker, J et al.
XRCC2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamideCancer Lett. Bd. 239. 2006 S. 305-313