Kurzfassung

In this study we aimed to profile tear fluid from 50 patients diagnosed with breast carcinoma and 50 healthy controls with the SELDI-TOF-MS technique. CM10 and WCX protein Chip surfaces were used. The identification of differently expressed proteins was performed with Matrix-Assisted Laser Desorption Ionisation Time of Flight (MALDI-TOF-TOF)-MS. One of the identified proteins was proline-rich protein 4 which is decreased in tear proteome of carcinoma patients. Its function remains unknown but...In this study we aimed to profile tear fluid from 50 patients diagnosed with breast carcinoma and 50 healthy controls with the SELDI-TOF-MS technique. CM10 and WCX protein Chip surfaces were used. The identification of differently expressed proteins was performed with Matrix-Assisted Laser Desorption Ionisation Time of Flight (MALDI-TOF-TOF)-MS. One of the identified proteins was proline-rich protein 4 which is decreased in tear proteome of carcinoma patients. Its function remains unknown but it might be involved in protective pathways.» weiterlesen» einklappen