Kurzfassung

Aldehyde dehydrogenase (ALDH) family encompassess 19 enzymes involved in detoxification of endogeneous and exogeneous aldehydes. In human cancers, enzymatic activities of different ALDH family members have been implicated in chemoresistance associated with cancer stem cells. In gliomas, ALDH expression was found to correlate with the grade of malignancy.Furthermore,several studies have shown that ALDH1 expression correlates with stemness characteristics and degree of aggressiveness in human...Aldehyde dehydrogenase (ALDH) family encompassess 19 enzymes involved in detoxification of endogeneous and exogeneous aldehydes. In human cancers, enzymatic activities of different ALDH family members have been implicated in chemoresistance associated with cancer stem cells. In gliomas, ALDH expression was found to correlate with the grade of malignancy.Furthermore, several studies have shown that ALDH1 expression correlates with stemness characteristics and degree of aggressiveness in human glioma stem cells. Although there is a substantial correlative evidence for the role of ALDH isoforms as predictive markers in gliomas, the ultimate proof is still missing. This project aims at delineating the role of ALDH1 isoforms A1 and A3 in radiochemoresistance mediated by glioma stem cells.» weiterlesen» einklappen