Kurzfassung

Cisplatin-based chemotherapy is the most common standard treatment for advanced bladder cancer. However, due to resistance development, prognosis remains poor and innovative therapeutic strategies are required. Thus, it is our objective to evaluate malignancy associated properties in a panel of “sensitive” and cisplatin-resistant bladder cancer cells. The genomic nanostructure of the cells and localization of “lead genes” will also be determined.