RNA-loaded functionalized nanoparticles for inhibition of tumor-associated regulatory T cells and antigen loading of human dendritic cells
Laufzeit: 01.01.2013 - 31.12.2017
Kurzfassung
(SFB 1066, Teilprojekt B07)
Objective of this project is to package inhibitory RNA molecules into functionalized polymers to inhibit immunosuppressive proteins in human regulatory T cells. Additionally, tumorantigen coding stimulatory RNA will be modified for synergistic antigen-loading and toll-like receptor-dependent activation of dendritic cells.
