Kurzfassung

Predicting glaucoma progression is a continuing challenge. Elevated intraocular pressure (IOP) is one of the most important risk factors for the development of glaucoma. Clinical trials of glaucoma treatment found that IOP lowering can retard glaucoma progression over a wide range of glaucoma stages and at different mean IOP levels. However, there is still no consensus as to whether short-term and long-term IOP fluctuation can be considered as independent risk factors for the development of...                                                                       
Predicting glaucoma progression is a continuing challenge. Elevated intraocular pressure (IOP) is one of the most important risk factors for the development of glaucoma. Clinical trials of glaucoma treatment found that IOP lowering can retard glaucoma progression over a wide range of glaucoma stages and at different mean IOP levels. However, there is still no consensus as to whether short-term and long-term IOP fluctuation can be considered as independent risk factors for the development of glaucoma and/or glaucoma progression defined as visual field changes and/or glaucomatous optic neuropathy

Purpose: To evaluate longitudinal IOP profile data, visual field (VF) and optic nerve head (ONH) data in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXE) and normal tension glaucoma (NTG).

Longitudinal data from the Dept. of Ophthalmology, Mainz were used for analysis. One hundred and forty-nine patients with continuous follow up data of at least 4 years and a minimum of seven 24-2 or 30-2 Humphrey SITA standard visual fields or Octopus visual fields and HRT images (at least 3 images) during a minimum of 4 years recorded between 1995 and 2009 were included. The proportion of patients with glaucoma progression was analysed using Kaplan-Meier estimates. The primary outcome variable was the incidence of VF progression events (visual field mean deviation/time and visual field pattern standard deviation/time). The secondary outcome variable was the incidence of HRT progression events (Topographic change analysis). 

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