Kurzfassung

Modern radiotherapy plays an important role in therapy of advanced head and neck carcinomas. However, no clinical studies have been published addressing the effectiveness of postoperative radiotherapy in patients with small tumor (pT1, pT2) and concomitant ipsilateral metastasis of a single lymph node (pN1), which would provide a basis for a general treatment recommendation.
The present study is a two-armed, non-blinded, prospective, multi-center randomized controlled trial (RCT) with the aim...Modern  radiotherapy plays an important role in therapy of advanced head and neck carcinomas. However, no clinical studies have been published addressing the effectiveness of postoperative radiotherapy in patients with small tumor (pT1, pT2) and concomitant ipsilateral metastasis of a single lymph node (pN1), which would provide a basis for a general treatment recommendation.
The present study is a two-armed, non-blinded, prospective, multi-center randomized controlled trial (RCT) with the aim to investigate the potential benefit of postoperative radiation treatment in this special cohort of patients. Inclusion criteria were histological verified oral or oropharyngeal carcinoma with a diameter less than 4 cm apart from grading, tumor-free resection margins (R0) and presence of a singular lymph node metastasis but without extracapsular spread or lymphangiosis carcinomatosa within the resection specimen on histological examination.» weiterlesen» einklappen