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Evaluation des Antioxidantienstatus und der fibrinolytischen Aktivität im Liquor und Serum von Patienten mit intrazerebralen und subarachnoidalen Blutungen

Laufzeit: 01.01.2017 - 31.12.2020

Kurzfassung


Primary objective: To determine antioxidant status (AO) and fibrinolytic activity (FA) in plasma and CSF of patients with aneurysmatic subarachnoid hemorrhage (aSAH) or intracerebral hemorrhage (ICH) over a 14-day time-course.

Secondary objectives: To assess correlations between AO-status / FA and the patients’ neurologic status as measured by the Stroke Impact Scale, the Glasgow Coma outcome scale-extended (GOSE), and the modified Rankin Scale (mRS), all tested at 6 months after the ictus.

The...
Primary objective: To determine antioxidant status (AO) and fibrinolytic activity (FA) in plasma and CSF of patients with aneurysmatic subarachnoid hemorrhage (aSAH) or intracerebral hemorrhage (ICH) over a 14-day time-course.
 
Secondary objectives: To assess correlations between AO-status / FA and the patients’ neurologic status as measured by the Stroke Impact Scale, the Glasgow Coma outcome scale-extended (GOSE), and the modified Rankin Scale (mRS), all tested at 6 months after the ictus.

The study is a single-center, prospective, observational study. All consecutive patients who will have an external ventricular drain (EVD) inserted for clinical reasons will be included.
 
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