Inhaltszusammenfassung

Control of autoaggressive T cells by regulatory T cells (Treg) is essential to ensuring peripheral tolerance. Several subsets of CD(4 ) T cells with suppressive properties have been described, including induced T helper (Th) type 3 and T regulatory (Tr) type 1 cells and naturally occurring CD(4 )CD(25 ) Treg. CD(4 )CD(25 ) Treg suppress the response of conventional T cells in a cell contact-dependent manner, whereas Th3 and Tr1 cells produce immunosuppressive cytokines. Two subsets of human C...Control of autoaggressive T cells by regulatory T cells (Treg) is essential to ensuring peripheral tolerance. Several subsets of CD(4 ) T cells with suppressive properties have been described, including induced T helper (Th) type 3 and T regulatory (Tr) type 1 cells and naturally occurring CD(4 )CD(25 ) Treg. CD(4 )CD(25 ) Treg suppress the response of conventional T cells in a cell contact-dependent manner, whereas Th3 and Tr1 cells produce immunosuppressive cytokines. Two subsets of human CD(4 )CD(25 ) Treg, characterized by expression of the integrins alpha4beta7 or alpha4beta1, are able to convey suppressive capacity to conventional CD(4 ) T cells, thereby generating Th suppressor cells (Th(sup)). One outstanding feature is the generation of Th(sup) with distinct properties. alpha4beta7 Treg induce Tr1-like interleukin (IL)-10-producing Th(sup), whereas alpha4beta1 Treg induce Th3-like Th(sup), which produce transforming growth factor (TGF)-beta. Thus, our findings reconcile contradictory results clearly demonstrating that suppression is contact dependent in vitro but mediated by soluble factors (IL-10 and TGF-beta) in vivo.» weiterlesen» einklappen

Autoren

Klassifikation

DFG Fachgebiet:
2.21 - Mikrobiologie, Virologie und Immunologie

DDC Sachgruppe:
Medizin