Inhaltszusammenfassung

CD25 T regulatory (Treg) cells play a central role regarding the maintenance of peripheral tolerance via suppression of autoaggressive CD4 T cells, CD8 T cells, and Th1 cells. In this study we demonstrate that CD25 Treg cells can also suppress the differentiation of murine conventional CD4 T cells toward Th2 cells in a contact-dependent manner. However, the cytokine production and proliferation of established Th2 cells could not be inhibited by freshly isolated CD25 Treg cells, whereas ...CD25 T regulatory (Treg) cells play a central role regarding the maintenance of peripheral tolerance via suppression of autoaggressive CD4 T cells, CD8 T cells, and Th1 cells. In this study we demonstrate that CD25 Treg cells can also suppress the differentiation of murine conventional CD4 T cells toward Th2 cells in a contact-dependent manner. However, the cytokine production and proliferation of established Th2 cells could not be inhibited by freshly isolated CD25 Treg cells, whereas a strong inhibition of differentiated Th2 cells by in vitro preactivated CD25 Treg cells could be observed. Inhibition of both conventional CD4 T cells and Th2 cells is accompanied by a strong enhancement of the expression of FoxP3 in the suppressed T cells. Hence, our study indicates that CD25 Treg cells have a therapeutic potential for Th2-mediated diseases and suggests a novel mechanism of suppression mediated by the transcriptional repressor FoxP3.» weiterlesen» einklappen

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Klassifikation

DFG Fachgebiet:
2.21 - Mikrobiologie, Virologie und Immunologie

DDC Sachgruppe:
Medizin