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Bioresorbable vascular scaffolds for percutaneous treatment of chronic total coronary occlusions occlusions : a meta-analysis

BMC cardiovascular disorders. Bd. 19. London: BioMed Central 2019 Art. 59

Erscheinungsjahr: 2019

ISBN/ISSN: 1471-2261

Publikationstyp: Zeitschriftenaufsatz

Sprache: Englisch

GeprüftBibliothek

Inhaltszusammenfassung


Background: BRS represent a new approach to treating coronary artery disease. Beneficial properties of BRS regardingthe restoration of vasomotility after resorption make themattractive devices in CTO revascularization. However,experience in this setting is limited. Methods: We systematically searched Medline, Scholar, and Scopus for reports of at least 9 patients with CTOundergoing BRS implantation. Patients’and procedural characteristics weresummarized. The primary outcome ofinterest wa...Background: BRS represent a new approach to treating coronary artery disease. Beneficial properties of BRS regardingthe restoration of vasomotility after resorption make themattractive devices in CTO revascularization. However,experience in this setting is limited. Methods: We systematically searched Medline, Scholar, and Scopus for reports of at least 9 patients with CTOundergoing BRS implantation. Patients’and procedural characteristics weresummarized. The primary outcome ofinterest was target lesion revascularization (TLR). Pooled estimates were calculated using a random-effectsmeta-analysis. The study protocol was registered in PROSPERO (CRD42017069322). Results: Thirteen reports for a total of 843 lesions with a median follow-up of 12 months (IQR 6–12) wereincluded in the analysis. At short-term, the summary estimate rate of TLR was 2.6% (95% CI: 1 to 4%, I2=0%,P=0.887)while at mid to long-term it was 3.8% (95% CI: 2 to 6%, I2=0%,P= 0.803). At long-term follow-up (≥12 months), thesummary estimate rate of cardiac death was 1.1% (95% CI: 0 to 2%, I2= 0%, P = 0.887). The summary estimate rates ofscaffold thrombosis and clinical restenosis were respectively 0.9% (95% CI: 0 to 2%, I2=0%,P= 0.919) and 1.8% (95% CI:0to4%,I2=0%,P= 0.448). Finally, the summary estimate rate of target vessel revascularization was 6.6% (95% CI: 0 to11%, I2=0%,P=0.04). Conclusions: Implantation of BRS in a population with CTO is feasible, although further longer-term outcome studiesare necessary.» weiterlesen» einklappen

Autoren


Polimeni, Alberto (Autor)
Anadol, Remzi (Autor)
Münzel, Thomas (Autor)
Geyer, Martin (Autor)
De Rosa, Salvatore (Autor)
Indolfi, Ciro (Autor)
Gori, Tommaso (Autor)

Klassifikation


DDC Sachgruppe:
Medizin