Microbe-focused glycan array screening platform
Proceedings of the National Academy of Sciences. Bd. 116. H. 6. Proceedings of the National Academy of Sciences 2019 S. 1958 - 1967
Erscheinungsjahr: 2019
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1073/pnas.1800853116
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Inhaltszusammenfassung
The interplay between glycan binding proteins and their carbohydrate ligands is fundamental to all aspects of life. Printed glycan arrays have helped to elucidate the role of glycans in many biological processes with monosaccharide resolution, particularly those of mammalian origin, over the past 15 y. Current microbial glycan arrays contain specialized small synthetic collections or isolated carbohydrates but better coverage is needed as microbes are enveloped in complex layers of carbohydra...The interplay between glycan binding proteins and their carbohydrate ligands is fundamental to all aspects of life. Printed glycan arrays have helped to elucidate the role of glycans in many biological processes with monosaccharide resolution, particularly those of mammalian origin, over the past 15 y. Current microbial glycan arrays contain specialized small synthetic collections or isolated carbohydrates but better coverage is needed as microbes are enveloped in complex layers of carbohydrates. The chemically diverse microbial glycans play crucial roles in immunity and infectious diseases. We present an extensive synthetic glycan collection focused on microbial glycans as a tool to investigate microbial glycobiology.» weiterlesen» einklappen
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Klassifikation
DFG Fachgebiet:
DDC Sachgruppe:
Chemie
