Inhaltszusammenfassung

NK cells and CTLs are key elements of the cellular immune response and eliminate pathogen‐infected and tumorigenic cells 1-3. Quantification of killer cell‐mediated cytotoxicity is of great importance in immunotherapy 4, 5, to predict cancer risk 6 and to improve antibody‐based treatments 7-9. A precise characterization of killer cell activity is also required to better understand the underlying molecular cytotoxic mechanisms 10-13. The time kinetic of the killing process reveals crucial info...NK cells and CTLs are key elements of the cellular immune response and eliminate pathogen‐infected and tumorigenic cells 1-3. Quantification of killer cell‐mediated cytotoxicity is of great importance in immunotherapy 4, 5, to predict cancer risk 6 and to improve antibody‐based treatments 7-9. A precise characterization of killer cell activity is also required to better understand the underlying molecular cytotoxic mechanisms 10-13. The time kinetic of the killing process reveals crucial information of killer cell activity. However, the standard endpoint cytotoxicity assays cannot obtain the time‐resolved killing kinetics efficiently, especially when the killer cells are in short supply. » weiterlesen» einklappen

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DDC Sachgruppe:
Biowissenschaften, Biologie