Kurzfassung

We will analyse the contribution of individual proteases to the generation of MHC ligands and to test the effect of chemical compounds on the established processing pathways. Proteins to be analysed include viral and tumor-derived proteins as well as proteins implicated in the development of autoimmunity.
The availability of mice with defects in the different proteases (different proteasomal subunit knock-out mice, PSA and BH knock-out mice) involved will allow us to verify the relevance of...We will analyse the contribution of individual proteases to the generation of MHC ligands and to test the effect of chemical compounds on the established processing pathways. Proteins to be analysed include viral and tumor-derived proteins as well as proteins implicated in the development of autoimmunity.
The availability of mice with defects in the different proteases (different proteasomal subunit knock-out mice, PSA and BH knock-out mice) involved will allow us to verify the relevance of the results obtained in vitro in an in vivo situation.
In addition, compounds that either selectively block the dominant processing activity or that skew processing towards the destruction of epitopes derived from viruses, autoantigens and tumor-associated or –specific proteins shall be identified.
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