Kurzfassung

Central reading center Mainz: The aim of the MRI acquisition within FIELD is to broaden our knowledge about frequency and kind of brain structural abnormalities in children with Fabry disease. The imaging findings can be associated to clinical, biomolecular, or genetic characteristics of the patients. Moreover, patients will be investigated repeatedly to detect possible structural changes longitudinally. Future investigations should enable comparison of the longitudinally observed children...Central reading center Mainz: The aim of the MRI acquisition within FIELD is to broaden our knowledge about frequency and kind of brain structural abnormalities in children with Fabry disease. The imaging findings can be associated to clinical, biomolecular, or genetic characteristics of the patients. Moreover, patients will be investigated repeatedly to detect possible structural changes longitudinally. Future investigations should enable comparison of the longitudinally observed children under ERT with an untreated natural history group to discover potential treatment effects on brain structure in this age group.» weiterlesen» einklappen