Ultra-High Field Sodium MRI in Alzheimer’s Disease Reveals Stage-dependent Metabolic Alterations Associated with Tau-pathology
Online. 2021
Erscheinungsjahr: 2021
Titel des mehrbändigen Werkes: ISMRM – The International Society for Magnetic Resonance in Medicine
Publikationstyp: Diverses (Konferenzband)
Sprache: Deutsch
Inhaltszusammenfassung
Deficits in brain cells’ homeostasis and metabolism are suspected to occur ahead of the atrophy observed throughout the brain of AD patients with potential interactions between Amyloid/Tau deposits and the Na/K-pump activity leading to increased cerebral sodium concentrations. Yet this increase remains to be confirmed. We present a multimodal imaging study combining structural 1H-MRI, quantitative 23Na MRI at 7T in association with Tau- and Amyloid-PET. We show that total sodium concentration...Deficits in brain cells’ homeostasis and metabolism are suspected to occur ahead of the atrophy observed throughout the brain of AD patients with potential interactions between Amyloid/Tau deposits and the Na/K-pump activity leading to increased cerebral sodium concentrations. Yet this increase remains to be confirmed. We present a multimodal imaging study combining structural 1H-MRI, quantitative 23Na MRI at 7T in association with Tau- and Amyloid-PET. We show that total sodium concentration is increased in multiple brain regions in AD compared to cognitively healthy controls, and that these changes are more strongly correlated with local Tau- than Amyloid-loads.» weiterlesen» einklappen
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Klassifikation
DDC Sachgruppe:
Ingenieurwissenschaften
