Prof. Dr. Florian Heigwer - Publikationen

Schubert, Antonia; Heigwer, Florian; Scheeder, Christian et al.
Image-based screens identify regulators of endogenous Dvl2 biomolecular condensates
BioRXiv: Cold Spring Harbor Laboratory 2025

Port, Fillip; Buhmann, Martha A.; Zhou, Jun et al.
Enhancedin vivogene knockout with undetectable off-targets using multiplexed Cas12a sgRNAs
BioRXiv: Cold Spring Harbor Laboratory 2024 bioRxiv 2024.11.26.625385

Hofman, Tomáš; Ng, Siu Wang; Garcés-Lázaro, Irene et al.
IFNγ mediates the resistance of tumor cells to distinct NK cell subsets
Journal for ImmunoTherapy of Cancer. Bd. 12. H. 7. BMJ 2024 S. e009410

Heigwer, Florian; Scheeder, Christian; Bageritz, Josephine et al.
A global genetic interaction network by single-cell imaging and machine learning
Cell Systems. Bd. 14. H. 5. Elsevier BV 2023 S. 346 - 362.e6

Funk, Maja C.; Gleixner, Jan G.; Heigwer, Florian et al.
Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice
Developmental Cell. Bd. 58. H. 24. Elsevier BV 2023 S. 2914 - 2929.e7

Prasad, Vibhu; Cerikan, Berati; Stahl, Yannick et al.
Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2
Molecular Cell. Bd. 83. H. 14. Elsevier BV 2023 S. 2559 - 2577.e8

Neufeldt, Christopher J.; Cerikan, Berati; Cortese, Mirko et al.
SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
Communications Biology. Bd. 5. H. 1. Springer Science and Business Media LLC 2022

Bamberg, Leonhard Valentin; Heigwer, Florian; Wandmacher, Anna Maxi et al.
Targeting euchromatic histone lysine methyltransferases sensitizes colorectal cancer to histone deacetylase inhibitors
International Journal of Cancer. Bd. 151. H. 9. Wiley 2022 S. 1586 - 1601

Port, Fillip; Strein, Claudia; Stricker, Mona et al.
A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila
eLife. Bd. 9. eLife Sciences Publications, Ltd 2020

Heigwer, Florian; Boutros, Michael
Cloud-Based Design of Short Guide RNA (sgRNA) Libraries for CRISPR Experiments
Fulga, Tudor A. u. a. (Hrsg). CRISPR Guide RNA Design. Springer US 2020 S. 3 - 22 (Methods in Molecular Biology ; 2162)

Scheeder, Christian; Heigwer, Florian; Boutros, Michael
Machine learning and image-based profiling in drug discovery
Current Opinion in Systems Biology. Bd. 10. Elsevier BV 2018 S. 43 - 52

Heigwer, Florian; Port, Fillip; Boutros, Michael
RNA Interference (RNAi) Screening inDrosophila
Genetics. Bd. 208. H. 3. Oxford University Press (OUP) 2018 S. 853 - 874

Heigwer, Florian; Scheeder, Christian; Miersch, Thilo et al.
Time-resolved mapping of genetic interactions to model rewiring of signaling pathways
eLife. Bd. 7. eLife Sciences Publications, Ltd 2018

Rauscher, Benedikt; Heigwer, Florian; Henkel, Luisa et al.
Toward an integrated map of genetic interactions in cancer cells
Molecular Systems Biology. Bd. 14. H. 2. Springer Science and Business Media LLC 2018

Caicedo, Juan C.; Cooper, Sam; Heigwer, Florian et al.
Data-analysis strategies for image-based cell profiling
Nature Methods. Bd. 14. H. 9. Springer Science and Business Media LLC 2017 S. 849 - 863

Scheeder, Christian; Heigwer, Florian; Boutros, Michael
HTSvis: a web app for exploratory data analysis and visualization of arrayed high-throughput screens
Bioinformatics. Bd. 33. H. 18. Oxford University Press 2017 S. 2960 - 2962

Heigwer, Florian; Zhan, Tianzuo; Breinig, Marco et al.
CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries
Genome Biology. Bd. 17. H. 1. Springer Science and Business Media LLC 2016 55

Rauscher, Benedikt; Heigwer, Florian; Breinig, Marco et al.
GenomeCRISPR - a database for high-throughput CRISPR/Cas9 screens
Nucleic Acids Research. Bd. 45. H. D1. Oxford University Press (OUP) 2016 S. D679 - D686

Winter, Jan; Breinig, Marco; Heigwer, Florian et al.
caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens
Bioinformatics. Bd. 32. H. 4. Oxford University Press (OUP) 2015 S. 632 - 634

Boutros, Michael; Heigwer, Florian; Laufer, Christina
Microscopy-Based High-Content Screening
Cell. Bd. 163. H. 6. Elsevier BV 2015 S. 1314 - 1325

Heigwer, Florian; Kerr, Grainne; Boutros, Michael
E-CRISP: fast CRISPR target site identification
Nature Methods. Bd. 11. H. 2. Springer Science and Business Media LLC 2014 S. 122 - 123

Heigwer, Florian; Kerr, Grainne; Walther, Nike et al.
E-TALEN: a web tool to design TALENs for genome engineering
Nucleic Acids Research. Bd. 41. H. 20. Oxford University Press (OUP) 2013 S. e190

Kitanovic, Ana; Bonowski, Felix; Heigwer, Florian et al.
Acetic acid treatment in S. cerevisiae creates significant energy deficiency and nutrient starvation that is dependent on the activity of the mitochondrial transcriptional complex Hap2-3-4-5
Frontiers in Oncology. Bd. 2. Frontiers Media SA 2012

Holenya, Pavlo; Heigwer, Florian; Wölfl, Stefan
KOMA: ELISA-microarray calibration and data analysis based on kinetic signal amplification
Journal of Immunological Methods. Bd. 380. H. 1-2. Elsevier BV 2012 S. 10 - 15

Holenya, Pavlo; Kitanovic, Igor; Heigwer, Florian et al.
Microarray‐based kinetic colorimetric detection for quantitative multiplex protein phosphorylation analysis
PROTEOMICS. Bd. 11. H. 10. Wiley 2011 S. 2129 - 2133