Induction of membrane chloride currents in Xenopus laevis oocytes by the sulfonyl amide sweeteners acesulfame K and saccharin
Journal of receptor and signal transduction research. Bd. 20. H. 2-3. England. 2000 S. 153 - 166
Erscheinungsjahr: 2000
ISBN/ISSN: 1079-9893
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.3109/10799890009150642
| Geprüft: | Bibliothek |
Inhaltszusammenfassung
Sweet receptors have remained elusive. In Xenopus oocytes sulfonyl amide sweeteners but not sweet compounds belonging to other chemical classes dose dependently induced membrane chloride currents via the inositol trisphosphate/calcium pathway. Induction of membrane currents was exclusively observed following extracellular application of sulfonyl amides but not by intracellular pressure injection, suggesting the involvement of a plasma membrane recepto...Sweet receptors have remained elusive. In Xenopus oocytes sulfonyl amide sweeteners but not sweet compounds belonging to other chemical classes dose dependently induced membrane chloride currents via the inositol trisphosphate/calcium pathway. Induction of membrane currents was exclusively observed following extracellular application of sulfonyl amides but not by intracellular pressure injection, suggesting the involvement of a plasma membrane receptor. The presence of this receptor in oocytes and the observed seasonal variation of the sweet response offers an opportunity for a molecular cloning approach.» weiterlesen» einklappen
Klassifikation
DDC Sachgruppe:
Biowissenschaften, Biologie
