On the reactivity of bromoperoxidase I (Ascophyllum nodosum) in buffered organic media: Formation of carbon bromine bonds
PURE AND APPLIED CHEMISTRY. Bd. 81. H. 7. 2009 S. 1251 - 1264
Erscheinungsjahr: 2009
ISBN/ISSN: 0033-4545
Publikationstyp: Zeitschriftenaufsatz
Doi/URN: 10.1351/PAC-CON-08-09-01
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Inhaltszusammenfassung
Peroxidase (PO) activity of vanadate(V)-dependent bromoperoxidase (BPO) I (Ascophyllum nodosum) [VBrPO(AnI)] was retained with a half-life time of similar to 60 days, if stored in H2O2-incubated, morpholin-4-ethane sulfonic acid (MES)-buffered aqueous alcoholic solutions. These conditions were applied for converting bromide and, e.g., methyl pyrrole-2-carboxylate into bromopyrroles with an almost quantitative peroxide yield. delta,epsilon-unsaturated alcohols furnished beta-bromohydrins and p...Peroxidase (PO) activity of vanadate(V)-dependent bromoperoxidase (BPO) I (Ascophyllum nodosum) [VBrPO(AnI)] was retained with a half-life time of similar to 60 days, if stored in H2O2-incubated, morpholin-4-ethane sulfonic acid (MES)-buffered aqueous alcoholic solutions. These conditions were applied for converting bromide and, e.g., methyl pyrrole-2-carboxylate into bromopyrroles with an almost quantitative peroxide yield. delta,epsilon-unsaturated alcohols furnished beta-bromohydrins and products of bromocyclization, i.e., tetrahydrofurans and tetrahydropyrans (70-84 % mass balance), if treated with H2O2, KBr, and VBrPO(AnI) in phosphate-buffered, CH3CN-diluted media. » weiterlesen» einklappen
