Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients
BMC cancer. Bd. 12. London: Springer 2012 Art. 562
Erscheinungsjahr: 2012
ISBN/ISSN: 1471-2407
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1186/1471-2407-12-562
| Geprüft: | Bibliothek |
Inhaltszusammenfassung
BACKGROUND: Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant systemic therapy (n = 766). METHODS: AURKA was analyzed using microarray-based gene-expression data from three independent cohorts of node-negative breast cancer patients. In multivariate Cox analyses, the prognostic impact of age, histological grade, tumor size, estrogen recept...BACKGROUND: Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant systemic therapy (n = 766). METHODS: AURKA was analyzed using microarray-based gene-expression data from three independent cohorts of node-negative breast cancer patients. In multivariate Cox analyses, the prognostic impact of age, histological grade, tumor size, estrogen receptor (ER), and HER2 were considered. RESULTS: Patients with higher AURKA expression had a shorter metastasis-free survival (MFS) in the» weiterlesen» einklappen
Autoren
Klassifikation
DFG Fachgebiet:
2.22 - Medizin
DDC Sachgruppe:
Medizin
