In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver disease
Journal of hepatology. Bd. 48. H. 1. Amsterdam: Elsevier 2008 S. 91 - 97
Erscheinungsjahr: 2008
ISBN/ISSN: 0168-8278
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1016/j.jhep.2007.07.029
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Inhaltszusammenfassung
BACKGROUND/AIMS: Histopathology is essential in the diagnostic workup of most liver diseases. However, biopsy sampling might carry risks, is subject to sampling error, and does not provide dynamic tissue imaging. Therefore a newly developed miniaturised confocal probe was evaluated for in vivo microscopic imaging in rodent models of human liver diseases. METHODS: The handheld laparoscopy probe used a 488nm single line laser for fluorophore excitation. Optical slice thickness was 7mum, lateral...BACKGROUND/AIMS: Histopathology is essential in the diagnostic workup of most liver diseases. However, biopsy sampling might carry risks, is subject to sampling error, and does not provide dynamic tissue imaging. Therefore a newly developed miniaturised confocal probe was evaluated for in vivo microscopic imaging in rodent models of human liver diseases. METHODS: The handheld laparoscopy probe used a 488nm single line laser for fluorophore excitation. Optical slice thickness was 7mum, lateral resolution 0.7mum. Imaging depth was 0-250mum below the tissue surface. Imaging using different fluorescent staining» weiterlesen» einklappen
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DDC Sachgruppe:
Medizin
