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Innate effector-memory T-Cell activation regulates post-thrombotic vein wall inflammation and thrombus resolution

Circulation research. Bd. 119. H. 12. New York, NY: Assoc. 2016 S. 1286 - 1295

Erscheinungsjahr: 2016

ISBN/ISSN: 0009-7330 ; 1524-4571

Publikationstyp: Zeitschriftenaufsatz

Sprache: Englisch

GeprüftBibliothek

Inhaltszusammenfassung


Rationale: Immune cells play an important role during the generation and resolution of thrombosis. T cells are powerful regulators of immune and nonimmune cell function, however, their role in sterile inflammation in venous thrombosis has not been systematically examined. Objective: This study investigated the recruitment, activation, and inflammatory activity of T cells in deep vein thrombosis and its consequences for venous thrombus resolution. Methods and Results: CD4+ and CD8+ ...Rationale: Immune cells play an important role during the generation and resolution of thrombosis. T cells are powerful regulators of immune and nonimmune cell function, however, their role in sterile inflammation in venous thrombosis has not been systematically examined. Objective: This study investigated the recruitment, activation, and inflammatory activity of T cells in deep vein thrombosis and its consequences for venous thrombus resolution. Methods and Results: CD4+ and CD8+ T cells infiltrate the thrombus and vein wall rapidly on deep vein thrombosis induction and remain in the tissue throughout the thrombus resolution. In the vein wall, recruited T cells largely consist of effector-memory T (TEM) cells. Using T-cell receptor transgenic reporter mice, we demonstrate that deep vein thrombosis–recruited TEM receive an immediate antigen-independent activation and produce IFN-γ (interferon) in situ. Mapping inflammatory conditions in the thrombotic vein, we identify a set of deep vein thrombosis upregulated cytokines and chemokines that synergize to induce antigen-independent IFN-γ production in CD4+ and CD8+ TEM cells. Reducing the number of TEM cells through a depletion recovery procedure, we show that intravenous TEM activation determines neutrophil and monocyte recruitment and delays thrombus neovascularization and resolution. Examining T-cell recruitment in human venous stasis, we show that superficial varicose veins preferentially contain activated memory T cells. Conclusions: TEM orchestrate the inflammatory response in venous thrombosis affecting thrombus resolution.» weiterlesen» einklappen

Autoren


Luther, Natascha (Autor)
Shahneh, Fatemeh (Autor)
Brähler, Melanie (Autor)
Krebs, Franziska (Autor)
Jäckel, Sven (Autor)
Subramaniam, Saravanan (Autor)
Stanger, Christian (Autor)
Schönfelder, Tanja (Autor)
Kleis-Fischer, Bettina (Autor)
Reinhardt, Christoph (Autor)
Probst, Hans Christian (Autor)
Wenzel, Philip (Autor)
Schäfer, Katrin (Autor)
Becker, Christian (Autor)

Klassifikation


DDC Sachgruppe:
Medizin