Institut für Physiologische Chemie und Pathobiochemie
Vorklinik / Johannes Gutenberg-Universität Mainz
Müller, WEG; Boreiko, A; Schloßmacher, U et al.
Identification of a silicatein(-related) protease in the giant spicules of the deep sea hexactinellid Monorhaphis chuniJ Exp Biol. Bd. 211. 2008 S. 300-309
Steiner, MA; Wanisch, K; Monory, K et al.
Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice.Pharmacogenomics J. Bd. 8. H. 3. 2008 S. 196-208
Waldron, E; Isbert, S; Kern, A et al.
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.Exp Cell Res. Bd. 314. H. 13. 2008 S. 2419-33
Izzo, AA; Aviello, G; Petrosino, S et al.
Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon.J Mol Med. Bd. 86. H. 1. 2008 S. 89-98
Czirr, E; Cottrell, BA; Leuchtenberger, S et al.
Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.J Biol Chem. Bd. 283. H. 25. 2008 S. 17049-54
Müller, WEG
IntronEncyclopedia of Science and Technology. 10. Aufl. New York: McGraw Hill 2008
Bringmann, G; Mutanyatta-Comar, J; Maksimenka, K et al.
Joziknipholones A and B: The first dimeric phenylanthraquinones, from the roots of Bulbine frutescensChem Eur J (Chemistry). Bd. 14. 2008 S. 1420-1429
Tamboli, IY; Prager, K; Thal, DR et al.
Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.J Neurosci. Bd. 28. H. 46. 2008 S. 12097-106
Bilbao, A; Parkitna, JR; Engblom, D et al.
Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.Proc Natl Acad Sci U S A. Bd. 105. H. 45. 2008 S. 17549-54
Waldron, Elaine; Heilig, Catherine; Schweitzer, Andrea et al.
Lrp1 modulates app trafficking along early compartments of the secretory pathwayNeurobiology of disease. Bd. 31. H. 2. Amsterdam: Elsevier 2008 S. 188 - 197
Thakur, NL; Jain, R; Natalio, F et al.
Marine molecular biology: an emerging field of biological sciencesBiotechnol Adv. Bd. 26. 2008 S. 233-245
Lukić-Bilela, L; Brandt, D; Pojskić, N et al.
Mitochondrial genome of Suberites domuncula: palindromes and inverted repeats are abundant in non-coding regionsGene. Bd. 412. 2008 S. 1-11
Moosmann, B; Behl, C
Mitochondrially encoded cysteine predicts animal lifespan.Aging Cell. Bd. 7. H. 1. 2008 S. 32-46
Kaandorp, JA; Blom, JG; Verhoef, J et al.
Modelling genetic regulation of growth and form in a branching spongeProc Biol Sci. Bd. 275. 2008 S. 2569-2575
Behl, C; Moosmann, B
Molekulare Mechanismen des Alterns. Über das Altern der Zellen und den Einfluss von oxidativem Stress auf den AlternsprozessU.M. Staudinger, H. Häfner (Hrsg). Was ist Alter(n)? Neue Antworten auf eine scheinbar einfache Frage. [Schriften der Mathematisch-naturwissenschaftlichen Klasse der Heidelberger Akademie der Wissenschaften, Nr. 18, 2008]. Berlin Heidelberg: Springer 2008
Behl, C
Morbus Alzheimer und weitere neurodegenerative ErkrankungenF. Holsboer, G. Gründer, O. Benkert (Hrsg). Handbuch der Psychopharmakotherapie. Heidelberg: Springer Medizin Verlag 2008
Shukoor, MI; Natalio, F; Tahir, MN et al.
Multifunctional polymer-derivatized γ-Fe2O3 nanocrystals as a methodology for the biomagnetic separation of recombinant His-tagged proteinsJ Magn Magn Mater. Bd. 320. 2008 S. 2339-2344
Jeong, WI; Osei-Hyiaman, D; Park, O et al.
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.Cell Metab. Bd. 7. H. 3. 2008 S. 227-35
Müller, WEG; Schloßmacher, U; Wang, X et al.
Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica-polymerase and silica-esterase)FEBS J. Bd. 275. 2008 S. 362-370
Moreira, FA; Kaiser, N; Monory, K et al.
Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.Neuropharmacology. Bd. 54. H. 1. 2008 S. 141-50
Wiens, M; Belikov, SI; Kaluzhanya, OV et al.
Regional and modular expression of morphogenetic factors in the demosponge Lubomirskia baicalensisMicron. Bd. 39. 2008 S. 447-460
Müller, WEG; Wang, X; Kropf, K et al.
Silicatein expression in the hexactinellid Crateromorpha meyeri: the lead marker gene restricted to siliceous spongesCell Tissue Res. Bd. 333. 2008 S. 339-351
Lutz, B; Monory, K
Soothing the seizures of children.Nat Med. Bd. 14. H. 7. 2008 S. 721-2
Proksch, P; Ebel, R; Edrada, RA et al.
Sponge-associated fungi and their bioactive compounds: the Suberites caseBotanica Marina. Bd. 51. 2008 S. 209-218
Storr, MA; Keenan, CM; Emmerdinger, D et al.
Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors.J Mol Med. Bd. 86. H. 8. 2008 S. 925-36
Klugmann, M; Szumlinski, KK
Targeting Homer genes using adeno-associated viral vector: lessons learned from behavioural and neurochemical studies.Behav Pharmacol. Bd. 19. H. 5-6. 2008 S. 485-500
Schröder, HC; Natalio, F; Wiens, M et al.
The 2'-5'-oligoadenylate synthetase in the lowest metazoa: isolation, cloning, expression and functional activity in the sponge Lubomirskia baicalensisMol Immunol. Bd. 45. 2008 S. 945-953
Sitz, JH; Baumgartel, K; Hammerle, B et al.
The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4.Neuroscience. Bd. 157. H. 3. 2008 S. 596-605
Moreira, FA; Lutz, B
The endocannabinoid system: emotion, learning and addiction.Addict Biol. Bd. 13. H. 2. 2008 S. 196-212
Martin, Anne M.; Kuhlmann, Christoph; Trossbach, Svenja et al.
The functional role of the second npxy motif of the lrp1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-d-aspartate receptorsJournal of biological chemistry. Bd. 283. H. 18. Bethesda, Md.: ASBMB 2008 S. 12004 - 12013
Hanstein, R; Lu, A; Wurst, W et al.
Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress.Neuroscience. Bd. 156. H. 3. 2008 S. 712-21
Price, DA; Seillier, A; Koek, W et al.
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cellEur J Neurosci. Bd. 29. 2008 S. 2177-86
Schneider, M; Spanagel, R; Zhang, SJ et al.
Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice.BMC Neurosci. Bd. 8. 2007 S. 105
Wilkesman, J; Schröder, HC
Analysis of serine proteases from marine sponges by 2-D zymographyElectrophoresis. Bd. 28. 2007 S. 429-436
Müller, WEG; Schlossmacher, U; Eckert, C et al.
Analysis of the axial filament in spicules of the demosponge Geodia cydonium: Different silicatein composition in microscleres (asters) and megascleres (oxeas and triaenes)Eur J Cell Biol. Bd. 86. 2007 S. 473-487
Müller, WEG; Li, J; Schröder, HC et al.
b) The unique skeleton of siliceous sponges (Porifera; Hexactinellida and Demospongiae) that evolved first from the Urmetazoa during the Proterozoic: a review.Biogeosciences. Bd. 4. 2007 S. 219-232
Yuece, B; Sibaev, A; Broedl, UC et al.
Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex.Neurogastroenterol Motil. Bd. 19. H. 9. 2007 S. 744-53
Agarwal, N; Pacher, P; Tegeder, I et al.
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.Nat Neurosci. Bd. 10. 2007 S. 870-9
Tremel, W; Shukoor, MI; Natalio, F et al.
Cell Specific Targeting of Multifunctional γ-Fe2O3 Nanoparticles Through Surface Binding of dsRNAMater Res Soc Symp Proc. Bd. 1088. 2007 S. I15-05
Gamerdinger, M; Clement, AB; Behl, C
Cholesterol-like effects of selective cyclooxygenase inhibitors and fibrates on cellular membranes and amyloid-beta production.Mol Pharmacol. Bd. 72. H. 1. 2007 S. 141-51
Müller, WEG; Belikov, SI; Kaluzhnaya, OV et al.
Cold stress defense in the freshwater sponge Lubomirskia baicalensis. Role of okadaic acid produced by symbiotic dinoflagellates.FEBS J. Bd. 274. 2007 S. 23-36
Aiello, A; Fattorusso, E; Giordano, A et al.
Damipipecolin and damituricin, novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella damicornis.Bioorg Med Chem. Bd. 15. 2007 S. 5877-5887
Brenz Verca, MS; Weber, P; Mayer, C et al.
Development of a species-specific RNA polymerase I-based shRNA expression vector.Nucleic Acids Res. Bd. 35. H. 2. 2007 S. 10
Maresz, K; Pryce, G; Ponomarev, ED et al.
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.Nat Med. Bd. 13. H. 4. 2007 S. 492-7
Finkenwirth, C; Schröder, HC; Roßbach, B et al.
DNA integrity in lymphocytes from subjects exposed to ozone in vivo determined by fast micromethodNaunyn Schmiedebergs Arch Pharmacol. Bd. 375. H. 1. 2007 S. 101
Shukoor, MI; Natalio, F; Ksenofontov, V et al.
Double-stranded RNA polyinosinic-polycytidylic acid immobilized onto gamma-Fe2O3 nanoparticles by using a multifunctional polymeric linker.Small. Bd. 3. 2007 S. 1374-1378
Schroder, JE; Tegeler, MR; Grosshans, U et al.
Dystroglycan regulates structure, proliferation and differentiation of neuroepithelial cells in the developing vertebrate CNS.Dev Biol. Bd. 307. H. 1. 2007 S. 62-78
Schröder, HC; Brandt, D; Schlossmacher, U et al.
Enzymatic production of biosilica glass using enzymes from sponges: basic aspects and application in nanobiotechnology (material sciences and medicine).Naturwissenschaften. Bd. 94. 2007 S. 339-359
Moser, N; Mechawar, N; Jones, I et al.
Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures.J Neurochem. Bd. 102. H. 2. 2007 S. 479-92
Müller, WEG; Eckert, C; Kropf, K et al.
Formation of giant spicules in the deep-sea hexactinellid Monorhaphis chuni (Schulze 1904): electron-microscopic and biochemical studies.Cell Tissue Res. Bd. 329. 2007 S. 363-378
Müller, WEG; Wang, X; Belikov, SI et al.
Formation of siliceous spicules in demosponges: example Suberites domunculaBäuerlein E (Hrsg). Handbuch of Biomineralization, Vol 1, Biological Aspects and Structure Formation. Weinheim: Wiley-VCH 2007
Müller, WEG; Boreiko, A; Schloßmacher, U et al.
Fractal-related assembly of the axial filament in the demosponge Suberites domuncula: Relevance to biomineralization and the formation of biogenic silicaBiomaterials. Bd. 28. 2007 S. 4501-4511
Lange, B; Metz, N; Tahir, MN et al.
Functional polymer-opals from core-shell colloidsMacromol Rapid Commun. Bd. 28. 2007 S. 1987-1994
Oliva, JM; Manzanares, J
Gene transcription alterations associated with decrease of ethanol intake induced by naltrexone in the brain of Wistar rats.Neuropsychopharmacology. Bd. 32. H. 6. 2007 S. 1358-69
Monory, K; Blaudzun, H; Massa, F et al.
Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice.PLoS Biol. Bd. 5. H. 10. 2007 S. e269
Berghuis, P; Rajnicek, AM; Morozov, YM et al.
Hardwiring the brain: endocannabinoids shape neuronal connectivity.Science. Bd. 316. H. 5828. 2007 S. 1212-6
Haring, M; Marsicano, G; Lutz, B et al.
Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice.Neuroscience. Bd. 146. H. 3. 2007 S. 1212-9
Finkenwirth, C; Schröder, HC; Roßbach, B et al.
In-vivo Studie zur DNA-schädigenden Wirkung einer akuten Ozonexposition - Bestimmung von DNA-Strangbrüchen in humanen Lymphozyten mittels der Fast Micromethod. 11. Symposium "Arbeitsphysiologie für Nachwuchswissenschaftler", MagdeburgAbstract-Band. Bd. P3. 2007 S. 999
Kuhlmann, CR; Tamaki, R; Gamerdinger, M et al.
Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruption.J Neurochem. Bd. 102. H. 2. 2007 S. 501-7
Czirr, E; Leuchtenberger, S; Dorner-Ciossek, C et al.
Insensitivity to Abeta42-lowering Nonsteroidal Anti-inflammatory Drugs and {gamma}-Secretase Inhibitors Is Common among Aggressive Presenilin-1 Mutations.J Biol Chem. Bd. 282. H. 34. 2007 S. 24504-13
Adell, T; Thakur, AN; Müller, WEG
Isolation and characterization of Wnt pathway-related genes from PoriferaCell Biol Int. Bd. 31. 2007 S. 939-949
Behl, C; Hartl, FU
Molekulare Mechanismen des AlternsPeter Gruss (Hrsg). Die Zukunft des Alterns. Die Antwort der Wissenschaft. Ein Report der Max-Planck-Gesellschaft. 1. Aufl. München: C.H. Beck 2007
Müller, WEG; Boreiko, A; Wang, X et al.
Morphogenetic activity of silica and bio-silica on the expression of genes controlling biomineralization using SaOS-2 cellsCalcif Tissue Int. Bd. 81. 2007 S. 382-393
Ebinger, M; Behl, C; Rosenhagen, M et al.
P-glycoprotein has negligible effects on estradiol and testosterone in mice.Neurosci Lett. Bd. 427. H. 1. 2007 S. 6-9
Müller, WEG; Wang, X; Zeng, L et al.
Phylogenetic position of sponges in early metazoan evolution and bionic applications of siliceous sponge spicules.Chin Sci Bull. Bd. 52. 2007 S. 1372-1381
Deshmukh, S; Onozuka, K; Bender, KJ et al.
Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex.Neuroscience. Bd. 145. H. 1. 2007 S. 279-87
Cetkovic, H; Mikoc, A; Müller, WEG et al.
Ras-like small GTPases form a large family of proteins in the marine sponge Suberites domuncula.J Mol Evol. Bd. 64. 2007 S. 332-341
Marsch, R; Foeller, E; Rammes, G et al.
Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice.J Neurosci. Bd. 27. H. 4. 2007 S. 832-9
Cota, D; Steiner, MA; Marsicano, G et al.
Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function.Endocrinology. Bd. 148. H. 4. 2007 S. 1574-81
Corbille, AG; Valjent, E; Marsicano, G et al.
Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants.J Neurosci. Bd. 27. H. 26. 2007 S. 6937-47
Moreira, FA
Serotonin, the prefrontal cortex, and the antidepressant-like effect of cannabinoidsJ Neurosci. Bd. 27. H. 49. 2007 S. 13369-70
Müller, WEG; Boreiko, A; Wang, X et al.
Silicateins, the major biosilica forming enzymes present in demosponges: protein analysis and phylogenetic relationship.Gene. Bd. 395. 2007 S. 62-71
Wang, X; Li, J; Qiao, L et al.
Structure and characteristics of gigant spicules of the deep sea hexactinellid sponges of the genus Monorhaphis (Hexactinellida: Amphidiscosida: Monorhaphididae).Acta Zoologica Sinica. Bd. 53. 2007 S. 557-569
Shukoor, MI; Natalio, F; Tahir, MN et al.
Superparamagnetic γ-Fe2O3 nanoparticles with tailored functionality for protein separationChem Commun. 2007 S. 4677-4679
Aguado, T; Romero, E; Monory, K et al.
The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis.J Biol Chem. Bd. 282. 2007 S. 23892-8
Lutz, B
The endocannabinoid system and extinction learning.Mol Neurobiol. Bd. 36. H. 1. 2007 S. 92-101
Patwardhan, SV; Shiba, K; Schröder, HC et al.
The interaction of 'silicon' with proteins - Part 2. The role of bioinspired peptide and recombinant proteins in silica polymerisationClarson SJ, Fitzgerald JJ, Owen MJ, Smith SD, Van Dyke ME (Hrsg). Science and Technology of Silicones and Silicone-modified Materials. Washington: American Chemical Society 2007
Ring, S; Weyer, SW; Kilian, SB et al.
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.J Neurosci. Bd. 27. H. 29. 2007 S. 7817-26
Wiens, M; Korzhev, M; Perovic-Ottstadt, S et al.
Toll-like receptors are part of the innate immune defense system of sponges (demospongiae: Porifera).Mol Biol Evol. Bd. 24. 2007 S. 792-804
Neumann, S; Schobel, S; Jager, S et al.
Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.J Biol Chem. Bd. 281. H. 11. 2006 S. 7583-94
Hajieva, P; Behl, C
Antioxidants as a potential therapy against age-related neurodegenerative diseases: amyloid Beta toxicity and Alzheimer's disease.Curr Pharm Des. Bd. 12. H. 6. 2006 S. 699-704
Wiens, M; Belikov, SI; Kaluzhnaya, OV et al.
Axial (apical-basal) expression of pro-apoptotic and pro-survival genes in the lake baikal demosponge Lubomirskia baicalensis.DNA Cell Biol. Bd. 25. 2006 S. 152-164
Müller, WEG; Schröder, HC; Belikov, SI
Biosilica, the raw material of the new millennium: sustainable production in Lake Baikal.Science-First Hand (in English). Bd. 1. 2006 S. 26-35
Kamprath, K; Marsicano, G; Tang, J et al.
Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes.J Neurosci. Bd. 26. H. 25. 2006 S. 6677-86
Domenici, MR; Azad, SC; Marsicano, G et al.
Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmission.J Neurosci. Bd. 26. H. 21. 2006 S. 5794-9
Sibaev, A; Massa, F; Yuce, B et al.
CB1 and TRPV1 receptors mediate protective effects on colonic electrophysiological properties in mice.J Mol Med. Bd. 84. H. 6. 2006 S. 513-20
Wiens, M; Müller, WEG
Cell death in Porifera: molecular players in the game of apoptotic cell death in living fossils.Can J Zool. Bd. 84. 2006 S. 307-321
Yoshinaga, M; Phan, TG; Nguyen, TA et al.
Changing distribution of group A rotavirus G-types and genetic analysis of G9 circulating in Japan.Arch Virol. Bd. 151. 2006 S. 183-192
Phan, TG; Kuroiwa, T; Kaneshi, K et al.
Changing distribution of norovirus genotypes and genetic analysis of recombinant GIIb among infants and children with diarrhea in Japan.J Med Virol. Bd. 78. 2006 S. 971-978
Annies, M; Bittcher, G; Ramseger, R et al.
Clustering transmembrane-agrin induces filopodia-like processes on axons and dendritesMol Cell Neurosci. Bd. 31. H. 3. 2006 S. 515-24
Schröder, HC; Boreiko, A; Korzhev, M et al.
Co-expression and functional interaction of silicatein with galectin: matrix-guided formation of siliceous spicules in the marine demosponge Suberites domuncula.J Biol Chem. Bd. 281. 2006 S. 12001-12009
Müller, WEG
Controlled formation of biosilicate nanostructuresPacific Rim Summit on Industrial Biotechnology and Bioenergy; Biotechnology Industry Organization, Honolulu, HI, 11.-13.01.2006; Abstract book. 2006 S. p. 46
Obradovic, D; Gronemeyer, H; Lutz, B et al.
Cross-talk of vitamin D and glucocorticoids in hippocampal cells.J Neurochem. Bd. 96. H. 2. 2006 S. 500-9
Müller, WEG; Müller, IM
Cultural heritage: Porifera (sponges), taxon successfully progressing palaeontology, biology, biochemistry, biotechnology and biomedicineAkademie gemeinnützige Wissenschaften zu Erfurt; Sitzungsberichte der Mathematisch-Naturwissenschaftlichen Klasse. Bd. 13. 2006 S. 95-139
Fouad, M; Edrada, RA; Ebel, R et al.
Cytotoxic isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.J Nat Prod. Bd. 69. 2006 S. 211-218
Okitsu-Negishi, S; Okame, M; Shimizu, Y et al.
Detection of norovirus antigens from recombinant virus-like particles and stool samples by a commercial norovirus enzyme-linked immunosorbent assay kit.J Clin Microbiol. Bd. 44. 2006 S. 3784-3786
Kern, A; Roempp, B; Prager, K et al.
Down-regulation of endogenous amyloid precursor protein processing due to cellular aging.J Biol Chem. Bd. 281. H. 5. 2006 S. 2405-13
Massa, F; Monory, K
Endocannabinoids and the gastrointestinal tract.J Endocrinol Invest. Bd. 29. H. 3 Suppl. 2006 S. 47-57
Müller, WEG; Müller, IM; Schröder, HC
Evolutionary relationship of Porifera within the eukaryotes.Hydrobiologia. Bd. 568. 2006 S. 167-176
Schröder, HC; Batel, R; Schwertner, H et al.
Fast micromethod DNA single-strand-break assay.Methods Mol Biol. Bd. 314. 2006 S. 287-305