Synthesis of two conformationally restricted piperazine scaffolds for combinatorial chemistry
European journal of organic chemistry. Bd. 2004. H. 20. Weinheim: Wiley-VCH 2004 S. 4113 - 4118
Erscheinungsjahr: 2004
ISBN/ISSN: 1434-193X
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1002/ejoc.200400358
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Inhaltszusammenfassung
Piperazines are widely used as central elements in the construction of bioactive molecules. Herein, the short synthesis of two chiral 2,6-bridged piperazines possessing orthogonally stable protecting groups from readily available starting materials is described. It is suggested that these molecules may be used as conformationally restricted scaffolds for the combinatorial synthesis of drug-like compounds. (C) Wiley-VCH Verlag GmbH Co.
Autoren
Opatz, Till (Autor)
Klassifikation
DDC Sachgruppe:
Chemie
