One-pot synthesis of polysubstituted pyrrolidines from aminonitriles
Synthesis. Bd. 2005. H. 6. Stuttgart: Thieme 2005 S. 945 - 956
Erscheinungsjahr: 2005
ISBN/ISSN: 0039-7881
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1055/s-2005-861838
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Inhaltszusammenfassung
alpha-Aminonitriles with a mono- or unsubstituted amino group as well as alpha(alkylideneaminomitriles can be employed as easily accessible alpha-aminocarbanion equivalents. Their alpha-deprotonation yields stabilized carbanions, which undergo smooth 1,4-addition to alpha,beta-unsaturated carbonyl compounds. The resulting delta-keto-alpha-aminonitriles can be reductively cyclized to form polysubstituted pyrrolidines.
Autoren
Meyer, N. (Autor)
Werner, F. (Autor)
Opatz, Till (Autor)
Klassifikation
DDC Sachgruppe:
Chemie
