A randomized trial of treatment for multisystem Langerhans' cell histiocytosis
Journal of pediatrics. Bd. 138. H. 5. St. Louis: Mosby 2001 S. 728 - 734
Erscheinungsjahr: 2001
ISBN/ISSN: 0022-3476
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1067/mpd.2001.111331
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Inhaltszusammenfassung
Objective: To compare 2 active agents, vinblastine and etoposide, in the treatment of multisystem Langerhans' cell histiocytosis (LCH) in an intel-national randomized study. Study design: One hundred forty-three untreated patients were randomly assigned to receive 24 weeks of vinblastine (6 mg/m(2), given intravenously every week) or etoposide (150 mg/m(2)/d, given intravenously for 3 days every 3 weeks), and a single initial dose of corticosteroids. Results: Vinblastine and etoposide were eq...Objective: To compare 2 active agents, vinblastine and etoposide, in the treatment of multisystem Langerhans' cell histiocytosis (LCH) in an intel-national randomized study. Study design: One hundred forty-three untreated patients were randomly assigned to receive 24 weeks of vinblastine (6 mg/m(2), given intravenously every week) or etoposide (150 mg/m(2)/d, given intravenously for 3 days every 3 weeks), and a single initial dose of corticosteroids. Results: Vinblastine and etoposide were equivalent (P greater than or equal to 2.2) in all respects: response at week 6 (57% and 49%); response at the last evaluation (58% and 69%); toxicity (47% and 58%); and probability of survival (76% and 80%), of disease reactivation (61% and 55%), and of del eloping permanent consequences (39% and 51%) including diabetes insipidus (22% and 23%). LCH reactivations were usually mild, as was toxicity. All children greater than or equal to2 years old without risk organ involvement (liver, lungs, hematopoietic system, or spleen) survived. With such involvement, lack of rapid (within 6 weeks) response was identified as a new prognostic indicator, predicting a high (66%,) mortality rate. Conclusions: Vinblastine and etoposide, with one dose of corticosteroids, are equally effective treatments for multisystem LCH, but patients who do not respond within 6 weeks are at increased risk for treatment failure and may require different therapy.» weiterlesen» einklappen
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DDC Sachgruppe:
Medizin
