Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question
Trends in immunology. Bd. 22. H. 1. Oxford: Elsevier 2001 S. 21 - 26
Erscheinungsjahr: 2001
ISBN/ISSN: 1471-4906
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1016/S1471-4906(00)01798-1
| Geprüft: | Bibliothek |
Inhaltszusammenfassung
T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of chronic mucosal inflammation in inflammatory bowel diseases (IBDs). Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD.
Autoren
Neurath, Markus F. (Autor)
Finotto, Susetta (Autor)
Fuss, Ivan (Autor)
Boirivant, Monica (Autor)
Galle, Peter R. (Autor)
Strober, Warren (Autor)
Klassifikation
DDC Sachgruppe:
Medizin
