Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
Science. Bd. 295. H. 5553. Washington, DC: American Assoc. for the Advancement of Science 2002 S. 336 - 338
Erscheinungsjahr: 2002
ISBN/ISSN: 1095-9203 ; 0036-8075
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1126/science.1065544
| Geprüft: | Bibliothek |
Inhaltszusammenfassung
Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4 cells from T-bet knockout mice spontaneously demonstrated...Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4 cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma. Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma.» weiterlesen» einklappen
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Medizin
