Illuminating the role of type I IFNs in colitis
The Journal of clinical investigation. Bd. 115. H. 3. Ann Arbor, Mich.: American Society for Clinical Investigation 2005 S. 586 - 588
Erscheinungsjahr: 2005
ISBN/ISSN: 0021-9738
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
Doi/URN: 10.1172/JCI200524518
| Geprüft: | Bibliothek |
Inhaltszusammenfassung
Recently, type I interferons IFN-alpha and IFN-beta (IFN-alpha/beta) have been evaluated in pilot clinical trials for the treatment of active ulcerative colitis. However, the underlying mechanisms that may contribute to a potential therapeutic effect are incompletely understood. A new study in this issue demonstrates a protective role for IFN-alpha/beta, induced by activation of a Toll-like receptor 9-dependent pathway, in a rodent model of experimental colitis.
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Klassifikation
DDC Sachgruppe:
Medizin
