Inhaltszusammenfassung

The aim of this study was to determine therapy-related risk factors for the development of second malignant neoplasm (SMN) after childhood cancer. The German Childhood Cancer Registry (GCCR) registers all childhood malignancies since 1980 including SMN. A nested case–control study with 238 SMN cases and 450 controls was conducted. A confirmatory, as well as an explorative, analysis was performed. Radiotherapy showed a small effect on the risk of SMN for doses 565 Gy. Regarding the chemotherap...The aim of this study was to determine therapy-related risk factors for the development of second malignant neoplasm (SMN) after childhood cancer. The German Childhood Cancer Registry (GCCR) registers all childhood malignancies since 1980 including SMN. A nested case–control study with 238 SMN cases and 450 controls was conducted. A confirmatory, as well as an explorative, analysis was performed. Radiotherapy showed a small effect on the risk of SMN for doses 565 Gy. Regarding the chemotherapeutical agents, we saw increased Odds Ratios (OR) for high doses of cyclophosphamide (CP >8000 mg/m2 OR=6.3 (95% Confidence Interval (CI): 1.3–30.2)), cisplatinum (DDP >435 mg/m2 OR=2.8 (95% CI: 1.1–6.7)) and mercaptopurine (MP >5000 mg/m2 OR=4.5 (95% CI: 1.1–18.9)). Patients jointly receiving high doses of MP (>5000 mg/m2) and dexamethasone (DEXA 51200 mg/m2) had an OR=6.9 (95% CI: 1.2–40.3). Our results could be added to those of other investigations to give indications for modifying future therapeutic strategies for childhood cancer.» weiterlesen» einklappen

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DDC Sachgruppe:
Medizin