Injured axons instruct Schwann cells to build constricting actin spheres to accelerate axonal disintegration
Cell reports. Bd. 27. H. 11. Maryland Heights, MO: Cell Press 2019 S. 3152 - 3166.e7
Erscheinungsjahr: 2019
ISBN/ISSN: 2211-1247
Publikationstyp: Zeitschriftenaufsatz
Sprache: Englisch
| Geprüft: | Bibliothek |
Inhaltszusammenfassung
After a peripheral nerve lesion, distal ends of injured axons disintegrate into small fragments that that are subsequently cleared by Schwann cells and later by macrophages. Axonal debris clearing is an early step of the repair process that facilitates regeneration. We show here that Schwann cells promote distal cut axon disintegration for timely clearing. By combining cell-based and in vivo models models of nerve lesion with mouse genetics, we show that this mechanism is induced by distal cu...After a peripheral nerve lesion, distal ends of injured axons disintegrate into small fragments that that are subsequently cleared by Schwann cells and later by macrophages. Axonal debris clearing is an early step of the repair process that facilitates regeneration. We show here that Schwann cells promote distal cut axon disintegration for timely clearing. By combining cell-based and in vivo models models of nerve lesion with mouse genetics, we show that this mechanism is induced by distal cut axons axons, which signal to Schwann cells through PlGF mediating the activation and upregulation of VEGFR1 in Schwann cells. In turn, VEGFR1 activates Pak1, leading to the formation of constricting actomyosin actomyosin spheres along unfragmented distal cut axons to mediate their disintegration. Interestingly Interestingly, oligodendrocytes can acquire a similar behavior as Schwann cells by enforced expression expression of VEGFR1. These results thus identify controllable molecular cues of a neuron-glia crosstalk crosstalk essential for timely clearing of damaged axons.» weiterlesen» einklappen
Autoren
Klassifikation
DDC Sachgruppe:
Biowissenschaften, Biologie
